Relationship Between Blood Homocysteine Level And Target Organ Damage In Middle-aged And Young Patients With Essential Hypertension

Objective:The relationship between the level of homocysteine(HCY)and major target organ damage in the heart,kidney and carotid artery in young and middle-aged patients with essential hypertension(EH).Methods: In November 2015 to November 2016 in the Department of Cardiology,the Fifth Affiliated Hospital of Xinjiang Medical University hospital in young EH patients with a total of 208 cases(including 145 cases of male,female 63 cases,mean age 45.34 + 6.69 years),were collected.The clinical data,biochemical data,heart and carotid artery ultrasound results calculated left ventricular mass index(LVMI)and the estimated glomerular filtration rate(eGFR),according to the serum HCY level of three points divided into three groups: group A(HCY <11.04umol/l),B group(HCY level between 11.04-16.17umol/l and C group(HCY)>16.17umol/ L),left ventricular mass index were compared between the three groups(LVMI),estimated glomerular filtration rate(eGFR),the difference of carotid artery abnormality.Results:1.There was no significant difference in age,body mass index(BMI),smoking duration,duration of hypertension,admission systolic blood pressure and admission diastolic blood pressure between the three groups(P>0.05),but there were differences in gender creatinine(Cr)(P<0.05).2.Correlation analysis showed that: A group,HCY level in patients with diastolic ventricular septal thickness(IVSTD),urea nitrogen(BUN)was significantly correlated(r=0.358,P=0.003),(r=0.246,P=0.043);in group C,LVMI and HCY level in patients with a significant correlation(r=0.274,P=0.024).3.Multiple linear regression analysis showed that higher HCY level was the main risk factor for estimating glomerular filtration rate(eGFR)and left ventricular mass index(LVMI)in young and middle-aged EH patients.Conclusion:Higher HCY level is an independent risk factor for heart damage and renal damage in young and middle-aged EH patients.