Clinical Study Of Qi Hong Powder Combined With Stage ? And Stage ? Cardiac Rehabilitation After Coronary Artery Bypass Grafting

Objective: To observe the efficacy and safety of Qi Hong powder(Qi Hong SAN)combined with stage I ~ II coronary artery bypass grafting(CABG)in patients with Qi deficiency and blood stasis after coronary artery bypass surgery.Methods: from April2016 to July 2017 in the diagnosis of cardiothoracic surgery,the Fourth Affiliated Hospital of Xinjiang Medical University for coronary heart disease and successfully underwent CABG,postoperative TCM syndrome of qi deficiency and blood stasis syndrome patients76 cases,randomly divided into combination of TCM and Western Medicine heart rehabilitation group(experimental group)and routine cardiac rehabilitation group(control group),38 cases in each group.The two groups were given conventional western medicine and conventional stage I and stage II cardiac rehabilitation,including exercise rehabilitation,psychological intervention,health education and other contents.On this basis,the experimental group was treated with traditional Chinese medicine Qi Hong powder for 12 weeks.Were observed after the treatment of NT-proBNP,LVEF,LVEDD,LVESD,6MWT,the efficacy of TCM syndrome score,Seattle Angina Questionnaire(SAQ)score and safety index,continued follow-up of 12 weeks,to observe the incidence of cardiovascular events in patients.Results:(1)After the treatment of two groups,the scores of NT-proBNP and TCM syndromes were significantly lower than before treatment(P<0.01).6MWT and SAQ scores were significantly higher than before treatment(P<0.01),and LVEF was significantly higher than before treatment(P<0.05).(2)The difference between groups before and after treatment was compared.The improvement of NT-proBNP and SAQ "angina pectoris" scores in the experimental group was better than that of the control group(P<0.05),the distance of 6MWT,the score of TCM syndrome and the scores of symptoms such as chest pain,chest tightness and secondary symptoms,such as shortness of breath and weakness,SAQ "level of physical activity limitation" and "satisfaction of treatment" and " degree of disease awareness" score improved significantly better than the control group(P<0.01),LVEF,LVEDD,LVESD,palpitation symptom of TCM Syndromes score,SAQ "angina stable state" score improvement degree group had no statistical difference(P>0.05).(3)After 12 weeks of treatment,the safety indexes of the two groups were not statistically different(P>0.1),and no adverse drug reactions were observed.After 24 weeks of observation,the incidence rate of compound end events was13.16% in the experimental group and 10.53% in the control group(P>0.1).The two groups had no severe barycenter adverse events.Conclusion: Qi Hong powder combined with stage I and stage II cardiac rehabilitation can significantly reduce the NT-proBNP,increase 6MWT distance,improve heart function and exercise ability,relieve clinical symptoms,improve life quality,the curative effect is remarkable.It is superior to conventional cardiac rehabilitation in reducing NT-proBNP,improving exercise ability and improving TCM syndromes,and has good safety.