| Backgroud and Objectives:Hepatic encephalopathy(HE)is the end stage of various kinds of liver diseases,also is the most common cause of death among them.HE include minimal hepatic encephalopathy(MHE)and overt hepatic encephalopathy(OHE).The mainstream view is that the intestinal flora imblance is considered to be associated with hepatic encephalopathy,and probiotics is play an important role in preventing bacterial translocation.However,it is rare that the results of clinical trials about probiotics and lactulose.The aim of this study was to evaluate efficacy and safety of probiotics and lactulose used in the therapy of MHE,using a mtea-analysis.Methods:A systematic literature search of the PubMed,Web of science,Embase,and Cochrane Library databases of clinical trials,Chinese Biomedical Literature database,Wanfang database,VIP database was conducted using specific search terms.Eligible studies were the randomized controlled trials regarding about The effects of probiotics prevent minimal hepatic encephalopathy,reported until February2018.We evaluate the efficacy of probiotics in the improvement minimal hepatic encephalopathy,progression to overt hepatic encephalopathy and the side effect compared to lactulose.Results:A total of 7 RCTs(combined n=442)were included in the meta-analysis,our study shown that,compared to lactulose,probiotics did not show a significant different in improvement in MHE(OR=0.86,95%CI:0.57-1.28,P=0.45),progression to OHE(OR=1.67,95%CI:0.79-3.56,P=0.18).However,probiotics appears to be more effective in reducing short-term side effects as compared to lactulose(OR=0.13,95%CI:0.05-0.33,P<0.0001).Conclusions:Probiotics was similar to lactulose in improvement MHE and progression toOHE,but more effective in reducing short-term side effects. |
