A Correlation Study Between Anemia And Short-term Prognosis Of Acute Cerebral Infarction

Objective1.Comparing the clinical features of patients with acute cerebral infarction(ACI)complicated by anemia.2.To study the association between anemia and short-term prognosis of patients with ACI.3.To investigate the association between different types of ACI combined with anemia and short-term poor prognosis.MethodsA total of 553 adult ACI patients hospitalized in our department of neurology from 2017-06 to 2017-12 were collected.According to the screening criteria of this study,476 patients were enrolled to collect hemoglobin,homocysteine,and platelet test data.The general information such as gender,age,hypertension,diabetes,history of atrial fibrillation,and smoking history were collected.Assess the neurological deficit and short-term prognosis(3 months)of these patients.Typing the patients with anemia associated with ACI by TOAST.To compare the clinical characteristics of patients with anemia and ACI,logistic regression analysis was used to study the independent risk factors of ACI short-term prognosis,and the correlation between different types of ACI combined with anemia and short-term prognosis was analyzed.Results1.Comparison of test data between patients with anemia and non-anemia: The hemoglobin(Hb)in the anemia group was lower than that in the non-anemic group(P<0.05).There was no significant difference in the incidence of platelet count and hyperhomocysteinemia between the two groups(P>0.05).2.The general conditions,risk factors,neurological deficits,and short-term prognosis of the two groups were compared: The anemia group was older,the prevalence of hypertension was higher,the neurological deficit was heavier,and the short-term prognosis was poor(P<0.05).There was no significant difference in gender,diabetes,smoking history and prevalence of atrial fibrillation between the twogroups(P>0.05).3.Using univariate analysis to screen relevant factors affecting ACI's short-term poor prognosis: anemia,hypertension,diabetes,age,smoking history,moderate and severe neurological deficits(NIHSS score >4 points),and short-term poor prognosis were statistically significant.(P<0.05).There was no significant correlation between sex,atrial fibrillation,platelet count,hyperhomocysteinemia and short-term prognosis(P>0.05).4.Logistic regression analysis was used to study the independent short-term prognosis risk factors of ACI: anemia(OR=2.862,P<0.05),moderate to severe neurological deficit(NIHSS score>4)(OR=5.471,P<0.05),smoking history.(OR=2.716,P<0.05),history of hypertension(OR=5.982,P<0.05),age(OR=1.090,P<0.05)was an independent risk factor for poor short-term prognosis.Diabetes history was not an independent risk factor for poor short-term prognosis(OR=1.049,P>0.05).5.Logistic regression analysis was used to investigate the association between different types of ACI combined anemia and short-term poor prognosis:Atherosclerotic ACI combined with anemia was independently associated with short-term prognosis(OR=4.797,P<0.05).Cardiogenic cerebral embolism There was no statistically significant correlation between ACI combined anemia and short-term prognosis(P>0.05).Conclusions1.The patients with anemia and ACI have older age,higher prevalence of hypertension,severe neurological deficits,and poorer short-term prognosis;2.Anemia,moderate-to-severe neurological deficit(NIHSS>4),age,history of hypertension,and smoking history were independent risk factors for short-term poor prognosis of ACI patients.3.Aortic atherosclerotic cerebral infarction with anemia is associated with a worse short-term prognosis.