Meta-analyses Of Candidate Genes For Schizophrenia

BackgroundSchizophrenia is a very serious mental disorder.Genetic factors play a particularly important role in the development of schizophrenia.The effects of random sampling error and genetic heterogeneity may make the results different and even some studies have opposite results.Meta-analyses can combine relevant data on genetic polymorphisms and schizophrenia to increase statistical power.ObjectivesTo screen genes that are more strongly associated with schizophrenia in order to screen for genetic markers of schizophrenia.Methods1.50 candidate genes identified based on convergent functional genomics and literature.2.50 genetic polymorphisms and schizophrenia genetic research literature were searched in the Pubmed,Embase,Web of science,Wanfang and CBM databases to screen for eligible case-control studies and to obtain the type data of target gene polymorphisms in the SZgene database.3.Quality assessment of included articles.4.Using Stata12.0 for data analysis.5.Study the function of genes through enrichment analysis and explore the interaction between proteins and proteins.Results1.Convergent functional genomics revealed the existence of 50 interacting genes.2.Allelic model results showed that 17 genes associated with schizophrenia were found based on the entire population.The subgroup analysis showed that there are 10 genes associated with schizophrenia in Asian populations and 10 genes associated with schizophrenia in European populations.3.In the recessive genetic model,based on the results of the entire population,it was found that there were associations between 12 loci on 11 genes and schizophrenia.4.In the dominant genetic model,based on the results of the entire population,it was found that there were associations between 11 loci on 10 genes and schizophrenia.5.Heterozygote model results showed association between 8 loci on 7 genes and schizophrenia.6.Homozygous model results showed that 12 loci on 9 genes are associated with schizophrenia.7.Enrichment analysis revealed that the functions of these genes are mainly related to terminal brain cell migration,dopamine metabolism,and neurotransmitter receptor activity.8.Finding that the DAO gene is the most crucial central gene by calculating the Degree Centrality,Closeness Centrality and Betweenness Centrality.Conclusions1.The Meta-analyses found 17,11,10,7,and 9 genes that were associated with schizophrenia in the allele model,the recessive model,the dominant model,the heterozygous model and the homozygous model,respectively.2.Numerous genes work together to increase the risk of schizophrenia.3.Genes associated with schizophrenia are involved in known biological functions in schizophrenia,further supporting the hypothesis of a polygenic genetic model for schizophrenia.