| bjective: To observe the clinical efficacy and safety of yang xin an mian drink on insomnia(Heart and Spleen Deficiency Syndrome)and to develop a standard solution of yang xin an mian drink and its clinical application,so as to provide the basis for promoting the use in the next step.Methods:(1)150 patientswhoMeet the experimental inclusion of insomnia were selected from the inpatients and outpatients of the The affiliated TCM hospital of Southwest MedicalUniversity from January 2016 to December 2017,.(2)The150patients were randomly divided into research group and control group,Each group of 75 cases,The control group was only given Psychologicalandbehavioraltherapy,theresearchgroup was given Psychological and behavioral therapy and yang xin an mian drink.Before treatment and after treatmentinonemonth,twogroupsofpatientswerepolysomnographicmonitoring,C hinese medicine syndrome score using the table before treatment and after treatmentforonemonthtocalculate the patient's TCM syndrome score,Pittsburgh Sleep Quality Index was used to assess the quality of sleep before treatment and after one month of treatment,Serum levels of dopamine(DA),serotonin(5-HT)and norepinephrine(NE)were measured by ELISA before treatment and after one month of treatment toEvaluate the clinical efficacy of both groups.(3)Statistical software SPSS19.0 is used for description and analysis of the data.Results:(1)The baseline data of the control group and the research group before treatment were compared:There was no significant difference in baseline data between the two groups before treatment(P>0.05).(2)Comparison of the indexes of the control group and research group before treatment:The difference between two groups in TCM syndrome score,Pittsburgh Sleep Quality Index score had no statistical significance(P >0.05).(3)The control group and research group before and after treatment and after treatment compared the indicators:After treatment,the TCM syndrome score and total score of the control group decreased compared with that before treatment,the difference was statistically significant(P <0.05);After treatment,the research group's TCM syndrome score and total score were significantly reduced compared with those before treatment,with significant difference,with statistical significance(P <0.01);After treatment,TCM syndrome scores were significantly different in the control group and research group(P <0.05);The control group Pittsburgh Sleep Quality Index score decreased after treatment than before treatment,the difference was statistically significant(P<0.05);The total score of Pittsburgh quality index in the research group after treatment was significantly lower than that before treatment(P <0.01);Pittsburgh quality index scores after treatment were different in two group(P<0.05);The levels of serum dopamine and norepinephrine in the control group were lower than those before the treatment,and the serum serotonin levels were significantly higher than those before treatment(P<0.05);After treatment,the levels of serum dopamine and norepinephrine in the research group were significantly lower than those before treatment,and the levels of serum serotonin in the research group were significantly higher than those before treatment(P<0.01).Comparison of two groups after treatment,The concentrations of serum DA and serum NE in the research group were significantly lower than those in the control group,and the serum 5-HT concentration was significantly higher than that in the control group(P <0.01)(4)The research group and control group after treatment efficacy comparison:After treatment,the overall curative effect of the two groups was significant(P<0.05),and the research group was superior to the control group.Conclusion:After treatmentof yang xin an mian drink,The scores of Pittsburgh sleep quality index and TCM syndromes in research group were significantly lower than those before treatment after treatment with yang xin an mian drink.The levels of serum dopamine and norepinephrine were significantly lower than those before treatment and the concentrations of serotonin were significantly higher than those before treatment,This shows that yang xin an mian medicine cure insomnia program better,IT Can significantly shorten the time to fall asleep,Extended sleep time,improve the quality of sleep,and improve the symptoms associated with insomnia,such as dizziness,dreams,wakefulness,fatigue,. |
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