| Purpose:To explore the clinical application of Zhigancao Tang Decoction in the treatment of coronary heart disease ventricular arrhythmias in the elderly.Objectively evaluate its clinical efficacy,symptoms of TCM improvement,safety and adverse reactions.Material and method : Select 44 patients admitted to the Department of Geriatrics and Inpatient Department of Wuhan First Hospital(Wuhan Integrative Medicine Hospital),whose ages are greater than or equal to 60,from February 2017 to January 2018,who was diagnosed as coronary heart disease ventricular arrhythmia,and with good compliance.According to a randomized control method,divide 44 patients into treatment group and control group,and 22 cases in each group.And the treatment group included 18 males and 4 females.The control group included 15 males and 7 females.Both groups were treated with conventional coronary heart disease medications(anti-platelet episodes,blood lipid regulation,tube expansion).In the control group,another amiodarone was given(dose: 0.4g-1.2g/d,2-3 times/d,and the patient's condition was reduced to 0.2g-0.4g/d after 2 weeks).The treatment group was supplemented with Zhigancao Tang Decoction on the basis of the use of the control group(provided by the First Hospital of Wuhan).its formula composition are Zhigancao 15 g,Shengdihuang 20 g,ginseng 10 g,Ophiopogon japonicus 10 g,hemp 10 g,jujube 10 g,cassia twig 9g,ginger 9g,donkey-hide gelatin 6g,Chuanxiong 6g,salvia miltiorrhiza 6g,angelica 10 g,White Pelican 5g.And its specific usage: taking two times a day after boiled,200 ml each time.After 4 weeks of the two groups were continuously treat,clinical symptoms,ambulatory electrocardiogram,premature ventricular contractions,TCM symptom scores,the three major routines,liver and kidney function,and specific adverse reactions were observed in both groups.Results:After statistical analysis,there was no statistical difference in the age distribution,gender composition and disease course distribution between the control group and the treatment group(P > 0.05).So the two groups are comparable.The total effective rate of the clinical symptoms of the treatment group was 86.36%,and the total effective rate of the control group was 59.09%.The therapeutic effect of the treatment group was better than that of the control group,and the difference was statistically significant(P < 0.05).After treatment,the number of 24-hour ventricular premature beats in the two groups decreased compared with that before treatment.The total effective rate of ventricular premature beat reduction in the treatment group was 90.91%,and the control group was 63.64%.The decrease of premature ventricular premature beats in the treatment group was more significant than that in the control group,and The total effective rate of the two groups was statistically significant(P<0.05).After treatment,the scores of TCM symptoms in both groups were lower than those before treatment.The TCM symptom scores after treatment in the control group were statistically significant compared with the control group(P<0.05).According to the TCM symptom score table,the TCM symptoms of the two groups were scored.There was no statistical difference between the two groups before the treatment(P>0.05).After treatment,the scores of TCM symptoms in both groups were lower than those before treatment.The difference was statistically significant(P<0.05),and the decrease in TCM syndrome scores in the treatment group was better than that in the control group(P<0.05).And the treatment group's TCM syndrome scores were lower than the control group.According to TCM symptom scores,the efficacy of TCM symptoms was evaluated in both groups.The total effective rate was 95.45% in the treatment group and 72.72% in the treatment group.The curative effect of the treatment group was better than that of the control group.And the total efficiency is statistically different.There were no abnormalities in safety indicators(blood routine,urine analysis,stool test,liver function,and renal function)before and after treatment in both groups.Only the control group experienced adverse reactions to dry mouth during the treatment and no special treatment was required.The patient continued treatment.After statistical treatment,both the control group and the treatment group were safe before and after treatment.Conclusion:This study found that after treatment,the patients in the treatment group had improvement in heart palpitations,shortness of breath,chest tightness,and tongue and pulse,which were more significant than those in the control group.Some patients completely disappeared after treatment.After treatment,the clinical symptoms and the frequency of ventricular premature beats in the two groups were improved to different degrees,and the therapeutic effect of the treatment group was better than that of the control group.On the basis of conventional western medicine treatment,adding Zhigancao Tang Decoction to treat ventricular arrhythmia in coronary heart disease can exert the effect of supplementing qi,activating blood circulation and removing blood stasis,and obtaining more significant effect than western medicine alone. |
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