| Objective: To observe the clinical efficacy and safety of serum bilirubin in liver cirrhosis treated with Yinzhi Shugan decoction through randomized controlled study.Methods: All subjects participating in this study came from our hospital's gastroenterology clinic and ward(October 2016 to October 2017),which met the Western medical diagnostic criteria for the clinical study of the disease.62 eligible subjects were selected.Randomly divided into 2 groups,31 cases in the control group and 31 cases in the treatment group.The control group was given conventional Western symptomatic supportive treatment.The treatment group was given Yinzhi Shugan Decoction(Yuanchen 30 g,Gardenia 10 g,Angelica 10 g,Angelica 10 g,Atractylodes 10 g,Poria 10 g,Bupleurum 6g,Yujin 10 g,Coix seed 30 g.,Bristles 10 g,Astragalus 15 g,Ganoderma lucidum 10 g,Tianjihuang 15 g,Begonia 10 g,Abrus cantoniensis 15 g.)Treatment,1 day,200 ml each morning and evening.Treatments are 4 weeks.Observe the changes of the main clinical symptoms,signs,and major laboratory parameters(TBIL,ALT,AST,GGT,ALP)before and after treatment,analyze the clinical efficacy,and observe the patient's three routine,electrocardiogram(ECG),liver and gallbladder Spleen pancreatic portal vein ultrasound and adverse drug reactions,etc.,to evaluate the safety of drugs.Results:(1)Comparison of overall curative effect: After 4 weeks,11 cases were markedly effective in the treatment group,14 cases were effective,6 cases were ineffective,the markedly effective rate was 34.48%,and the total effective rate was 80.65%.In the control group,9 cases were markedly effective and 13 cases were effective.In 9 cases,the significant rate was 29.03%,and the total effective rate was 70.97%.There was a statistically significant difference between the two groups(P<0.05).The significant rate and total effective rate in the treatment group were higher than those in the control group.(2)Comparison of TCM symptoms: After 4 weeks,the treatment group recovered 4 cases clinically,19 cases were markedly effective,5 cases were effective,2 cases were ineffective,the effective rate was 74.19%,the total effective rate was 90.32%,and the control group was cured clinically in 2 cases.9 cases were markedly effective,15 cases were effective,5 cases were ineffective,the effective rate was 35.48%,and the total effective rate was 83.87%.The number of recovered patients in the treatment group was significantly higher than those in the control group,P=0.036<0.05.There was statistical significance.(3)Comparison of TCM symptom scores: After 4 weeks,the TCM symptom score of the control group was 8.677± 1.939,and the TCM symptom score of the treatment group was 7.419± 1.566.P values were <0.001 for each group compared with before treatment.Significance,indicating that the total scores of TCM symptoms were improved after treatment in both groups;and after treatment,the TCM symptom scores of the treatment group and the control group were compared,P=0.007<0.01,which was statistically significant,indicating that the TCM group between the two groups after treatment There is a difference in the total score of symptoms,and the treatment group has a more significant effect.(4)Comparison of scores of major TCM symptoms: Compared with the control group,the main symptoms of TCM symptoms in the treatment group were improved yellowing of the body,pain in the flank,yellow urine,tiredness and fatigue,and loss of appetite.Among them,yellow dyeing was improved.The most obvious(P<0.001),drowsiness and fatigue improved(P<0.01),and rib pain,loss of appetite,and urine erythema were improved after treatment(P<0.05);after treatment in both groups compared with before treatment Both had P<0.01 or P<0.001,and the difference was statistically significant,indicating that both groups had significant effects after treatment,and the main TCM symptoms of the treatment group improved significantly.(5)Comparison of important laboratory indicators before and after treatment: After 4 weeks,the main laboratory indicators of the treatment group compared with the control group,the treatment group TBIL decreased significantly compared with before treatment(P <0.01),ALT,AST decreased significantly(P <0.05)There was no significant difference between the GGT and ALP treatment groups and the control group after treatment.After treatment in each group compared with before treatment,there was P<0.01,the difference was statistically significant,indicating that the treatment effect of each group after treatment was significantly better than before treatment.Taken together,the treatment group had a better treatment effect,especially the most significant change in each group before and after TBIL treatment.Conclusion: This clinical observation shows that the use of Yinqi Shugan Decoction in the treatment of liver cirrhosis with serum bilirubin increases the bile excretion and improves the intrahepatic cholestatic condition,so as to promote the regression of jaundice and improve the clinical symptoms of patients.Other purposes.At the same time,Yinqi Shugan Decoction also has a good clinical effect of hepatoprotection and down-regulation,and the use of drugs is safe.No obvious adverse reactions were found during the study,which demonstrated the advantages of this side in the treatment of hepatic cirrhosis with elevated serum bilirubin,which deserves further research and clinical promotion. |
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