Clinical Observation On Effect Of Berberine In Treatment Of Ulcerative Colitis

ObjectivesThe occurrence of ulcerative colitis(UC)is closely related to the intestinal inflammatory response,the destruction of the barrier function of the intestinal mucosa and the imbalance of the intestinal flora.At present,berberine has been used to reduce inflammatory reactions and has achieved good results.As an adjuvant therapy for UC,berberine has become a research hot spot,but its efficacy and safety are yet to be evaluated clinically.This study investigated the clinical efficacy and incidence of adverse reactions of berberine in and mesalazine in the treatment of mild and moderate ulcerative colitis,and further analyzed the possible mechanism of berberine in the treatment of ulcerative colitis.provide a new therapeutic approach and theoretical basis for the prevention and treatment of ulcerative colitisMethodsSelect 60 patients who accord with the standard of diagnosis of mild-moderate ulcer colitis in No.175 PLA Hospital from December 2015 to June 2017.All the enrolled patients were diagnosed after combining clinical examination,colonoscopy,and pathology.For ulcerative colitis,which is consistent with the clinical diagnostic criteria for mild to moderate ulcerative colitis,60 patients were randomly divided into control and experimental groups.The control group was given mesalazine enteric-coated capsule orally,1g,ter in die for 8 weeks.The experimental group continued to be given berberine hydrochloride orally,0.3g,ter in die,on the basis of the control group,continuous treatment for 8 weeks.Records of clinical symptoms,changes in colonoscopy,pathological changes,and incidence of adverse drug reactions were recorded before and after treatment in both groups.ResultsAfter 8 weeks of drug treatment,the total effective rate of the experimental group was compared with the control group,the total effective rate in the control group was 86.67%,the total effective rate in the experimental group was 93.33%,P<0.05,there was a significant difference.The remission rates of clinical symptoms such as abdominal pain,diarrhea,tenesmus,and mucocus and bloody stool were all significantly different(P<0.05).The comparison between the two groups under colonoscopy showed that the number of cured,markedly effective,and progressive cases in the experimental group was 6,13,and 6 cases,the effective rate was 88.33%.In the control group,the number of cured,markedly effective,and progressive cases were 3,12,and 5,respectively,and the effective rate was 66.67%,P<0.05.There was a significant difference.The adverse reactions such as nausea,vomiting,dizziness,headache,and leucopenia occurred after taking mesalazine and berberine in the two groups were 13.33%in the experimental group and 16.66%in the control group,P>0.05,which was not statistically significant.ConclusionsThe curative effect that berberine combined with mesalazine entericcoated tablets in the total effective rate,clinical symptoms,colonoscopic remission of mild-moderate ulcerative colitis is better than that of single application of mesalazine,and the patient’s adverse reactions There is no significant difference in the incidence rate.