| Objective:1.Based on metabolism of western medicine treatment,the observation tradit-ional Chinese medicine(TCM)stilbene kwai particles on early type 2 diabetic kidney qi and Yin deficiency,dampness stasis blocking collaterals syndrome proteinuria and blood glucose,blood pressure,the influence of and the early clinical efficacy and safety of patients with type 2 diabetes kidney disease.2.Early detection of diabetes kidney disease in patients with urinary retinol binding protein(RBP),urinary n-acetyl-beta-D-glycosidase enzymes(NAG)concentration,urine beta 2 microglobulin(beta 2-MG),and explore the stilbene kwai particle effects on renal tubular damage index.Methods:A randomized,parallel control clinical study design was adopted.In this study,60 patients with microalbuminuria of early diabetic nephropathy were selected and randomly divided into Chinese medicine group and control group according to the order of inclusion.The control group was given basal metabolic therapy intervention,and basal metabolic therapy included blood glucose,blood pressure and blood lipid treatment.On the basis of the control group,the traditional Chinese medicine group was used to take the qi kwai granule,and the observation period was 6 months.Observed indicators:Urinary ACR?UTP?Blood sugar?Blood pressure;Urinary RBP?Urinary NAG enzyme concentration?Urinary beta 2-MG;Blood routine?Urine routine?Liver and kidney function.Result:1.The total effective rate of the Chinese medicine group was 76.67%,among which 5 were effective.18 were effective and 7 were ineffective.The total effective rate of the control group was 20%,among which 1 case was effective,5 cases were effective and 24 were invalid.The difference between the two groups was statistically significant(P<0.05),and the efficacy of Chinese medicine group was significantly better than that of the control group.2.Comparison of TCM syndromes in TCM syndromes:the decline trend of TCM syndromes in traditional Chinese medicine group was better than that of the control group(P<0.05).3.Chinese medicine group UACR and UTP value,before treatment:80.46±46.26mg/g,107.09±79.97mg/24h,after treatment:47.37±23.00mg/g,56.57±24.37mg/24h;Control group UACR,UTP value,before treatment:78.30±32.27mg/g,97.17±27.54mg/24h,after treatment:59.77±23.30mg/g,69.13±23.96mg/24h.After treatment,both UACR and UTP values were lower than before treatment,with statistical difference(P<0.05),and the efficacy of Chinese medicine group was better than that of the control group(P<0.05).4.The urinary RBP,urine NAG enzyme concentration and urine were 2-mg in the traditional Chinese medicine group,before treatment:54271.67±10212.29ng/mL,36.23±10.17u/L,0.54+0.17 mg/L,and after treatment:34716.88±5190.76ng/mL,17.07 plus or minus 5.24u/L,0.27±0.08mg/L;Inthe control group,urinary RBP,urine NAG enzyme concentration and urine were 2-mg,before treatment:52223.52±11548.38ng/imL,38.43±8.37u/L,0.52±0.13mg/L,after treatment:38645.36±6272.36ng/mL,22.80±8.52u/L,0.36±0.09 mg/L.After treatment,two groups of urinary RBP,NAG enzyme concentration and urine output were all lower than before treatment,with statistical significance(P<0.05),and the level of urinary RBP,NAG enzyme concentration and urine output in the traditional Chinese medicine group was better than that in the control group(P<0.05).5.There was no obvious adverse reaction in the two groups during the treatment.Conclusion:1.Astragalus granule can improve the clinical symptoms of the patients with the deficiency of qi Yin and Yin deficiency of the patients with the disease.2.Astragalus granule is effective in the treatment of early DKD proteinuria.It can not only improve the symptoms such as proteinuria,but also play a role of kidney protection.3.Astragalus granule can improve the urinary RBP,NAG enzyme concentration,and urine of the DKD patients,which may be protective to the renal tubule injury. |
PDF Full Text Request