Observation Of Clinical Effect On Regulating Spleen And Kidney Method For The Treatment Of Senile Constipation

Objective:To observe the clinical effect and safety of regulating spleen and kidney method for the treatment of senile constipation with spleen and kidney deficiency so as to provide guidance for clinical treatment by collecting clinical cases and following-up.Methods:60 elderly patients who were conformed to diagnostic standards of chronic constipation were divided into treatment group 30 cases and control group 30 cases.The treatment group and control group were treated with Yun Pi Yi Shen decoction and the polyethylene glycol 4000 powder(Forlax).The whole treatment lasted for 4 weeks.Then evaluated the proportion of patients with more than 3 times SCBM,changes of Bristol stool rating scale and the score of effective rate of TCM symptoms,average PAC-QOL score.Followed up to observe the proportion of patients with more than 3 times SCBM and total score of TCM symptoms in 2 weeks after the treatment.The efficacy and safety were evaluated by spss 20.0 statistical analysis.Results:After the end of treatment,60 patients had completed the study.During the 4 weeks,the proportion of patients with SCBM>3 times per week of treatment group and control group were 40%and 36.7%respectively.The data was no significant difference(P>0.05).The proportion of patients with more than 3 times SCBM per week on average in the first 2 weeks was 33.3%and 36.7%in treatment group and control group separately.At last 2 weeks of whole treatment the results were 43.3%and 33.3%respectively.The two dates were no significant difference after statistical comparison(P>0.05).4 weeks after treatment,cases of Bristol stool changed into 4-7 types in treatment group and control group were 25 and 26 respectively.Treatment group had similar effect on stool characteristics compared with control group(P>0.05).After 4 weeks,treatment group had better effect on improving difficult defecation,relieving defecation endless feeling,weak waist,loss of appetite and the total score(P<0.05).The total effective rate of TCM of the treatment group and the control group was 90%and 70%respectively.There was statistical difference between two groups(P<0.05),indicating that the treatment group was more effective than the control one.The treatment group's average PAC-QOL score was 77.33± 14.65,as the control group 77.83± 13.86,the date had no statistical significance.Followed up 2 weeks,the proportion of patients with SCBM>3 times per week had no difference(P>0.05),the total score of TCM symptoms of treatment also had no significant difference(P>0.05).During the treatment,the most frequent side reactions were diarrhea and bloating.Two groups of patients did not appear serious side reactions.Conclusion:Regulating spleen and kidney method for the treatment of senile constipation significantly improved defecation,associated symptoms and quality of life.It had more advantages than polyethylene glycol 4000 powder(Forlax)in improving scores of TCM symptoms,and was safe.