| BackgroundThe prognosis of cancer patients is related to their nutritional status,and which has attracted more and more attention.A number of meta-analysis of gastrointestinal tumors found that the prognostic nutritional index(PNI)was positively related to the overall survival(OS)of gastrointestinal tumors,but there was no large study of the relationship between PNI and the survival of the patients with non-small cell lung cancer.The role of prognostic nutritional index in patients with non-small cell lung cancer(NSCLC)was investigated in this meta-analysis.MethodUntil October 2017,in PubMed and Web of Science,a literature search was performed.The key search items were("PNI" OR "The prognostic nutritional index");("lung cancer" OR "lung tumor" OR "lung carcinoma" OR "lung neoplasm" OR "NSCLC" OR "non-small cell lung cancer" OR "non-small lung cancer"OR "non-small lung tumor" OR "non-small lung carcinoma" OR "non-small lung neoplasm").For a comprehensive search of the relevant literature,a total of 66 related studies,and the references cited in the relevant literature to be retrieved.The literature was screened out by exclusion and inclusion criteria.Finally,7 articles were included in our study.According to the Newcastle Ottawa Scale(NOS),the quality of the 7 literature was evaluated,and then the meaningful data in 7 studies were extracted by two independent researchers.the Hazard ratio(HR)and the corresponding 95%CI of the recurrence-free survival(RPS)in the relationship between the prognostic nutrition index and the recurrence-free survival in the related studies were calculated in a multivariate analysis.The Stata SE 12 software was used to calculate the combined HR respectively as the effect to evaluate the correlation between the prognostic nutritional index and the development of non-small cell lung cancer,and HR>1 suggested that the prognosis was poor,In addition,the Hazard ratio(HR)and the corresponding 95%confidence interval(CI)in the relationship between the prognostic nutrition index and overall survival(OS)in the related studies were calculated by both univariate analysis and multivariate analysis respectively,and the total HR of the relationship between the prognostic nutrition index and overall survival was calculated by the Stata SE 12 software.HR>1 showed a poor prognosis.At the same time,the relationship between the prognostic nutrition index and the characteristics of patients with non-small cell lung cancer(including the relationship between pathological type and age)was also analyzed,and the total HR and its corresponding 95%CI were calculated.ResultThis study analyzed 7 studies involving 2827 patients.The non-small cell lung cancer patients with low prognostic index usually have a low overall survival(OS),the HR was 1.60(95%CI:1.38-1.80),and they also have a low the recurrence-free survival(RFS),and the HR was 2.20(95%CI:1.55-3.12).At the same time,we also analyzed the relationship between the age and pathological types of non-small cell lung cancer patients and the prognosis nutritional index.The study found that the nutritional index of the elderly patients was low,and the HR was 1.285(95%CI:1.142-1.446).The high prognosis nutrition index suggested that the patients were more likely to be adenocarcinoma,and the total risk ratio was HR:1.14(95%CI:1.041-1.248).conclusionThe meta-analysis showed that the prognostic nutritional index is a prognostic factor in patients with non-small cell lung cancer.The overall survival and the recurrence-free survival in patients with non-small cell lung cancer who had low nutritional index were poor.In addition,this meta-analysis also indicates that the prognostic nutritional index of elderly patients is low,and the patients with high prognostic nutritional index more likely to be with Adenocarcinoma. |
PDF Full Text Request