| Objective: Observe the clinical treatment efficacy of Chai Huang Qing Yi Huo Xue Granule in patients with severe acute pancreatitis(SAP)to provide evidence for its clinical application as a new drug in future SAP management.Methods: 60 patients with severe acute pancreatitis who were hospitalized in the spleen and gastroenterology department of the Affiliated Chinese Medicine Hospital of Southwest Medical University from January 2017 to April 2018 were enrolled in this study with indicated inclusion and exclusion criteria.The 60 patients were randomly assigned into treatment group and control group,with 30 cases in each group.Both groups were given basic treatment.Patients in the treatment group were supplemented with Chai Huang Qing Yi Huo Xue Granule by both intragastrical(orally)and enema administration.Patients in the control group were supplemented with Qing Yi Li Dan Granule by both intragastrical(orally)and enema administration.The disease symptoms,physical signs,serum amylase,white blood cell count,serum calcium ion,APACHE II score,BISAP score,and MCTSI score of the enrolled patients were analyzed at hospitalized day and the afterward 3rd,and 7th days.Furthermore,patient's first time of spontaneous defecation and farting,time of abdomen pain relief,total hospitalization day were also compared between the two groups.Results: 1.Comparison of overall effective rate: The overall effective rate in the treatment group(93.3%)was higher than that in the control group(73.3%)with statistical significance(P<0.05).2.Comparison of disease symptom quantification scores: Patients in both two groups showed decreased symptom quantification scores on the 3rd and 7th days after compared with that of the hospitalization day(P<0.05).However,on the 7th day,the treatment group showed lower symptomatic scores than that in the control group(P<0.05).3.Comparison of physical signs quantification scores: The physical signs quantification scores in both groups on the 3rd and 7th day were significantly lower than those at the time of hospitalization(P<0.05).On the 7th day,the reduction in the physical signs quantitative scores of patients in the treatment group was significantly greater than in the control group(P<0.05).4.Comparison of serum amylase: Serum amylase levels at the 3rd and 7th days of the two groups were significantly lower than those of hospitalization day(P<0.05).However,no difference of serum amylase level can be observed between the two groups(P>0.05).5.Comparison of white blood cell count: The white blood cell counts of patients in the two groups on the 3rd and 7th days were significantly lower than those at the time of hospital hospitalization(P<0.05).On the 3rd and 7th days,the decrease of white blood cell count in the treatment group was more robust than that in the control group(P<0.05).6.Comparison of calcium ion: The calcium ion level on the 3rd day of the two groups was lower than that at the time of hospitalization(P<0.05).The level of calcium ion on the 7th day increases and shows no difference with that at the time of hospitalization(P>0.05).On the 3rd and 7th days,there was no significant difference of the calcium level between the two groups(P>0.05).7.Comparison of APACHE II scores: The APACHE II scores on the 3rd and 7th days of the two groups were significantly lower than those on hospitalization day(P<0.05).On the 3rd and 7th days,the APACHE II score decreased more significantly in the treatment group than in the control group(P<0.05).8.Comparison of BISAP scores: BISAP scores were significantly decreased on the 3rd and 7th days of the two groups compared with those on hospitalization day(P<0.05).Compared with the control group on the 7th day,the treatment group reduced the BISAP score more significantly,the difference was statistically significant(P<0.05).9.Comparison of MCTSI scores: There was no significant difference between the two groups of patients on the 3rd day compared with the day of hospitalization(P>0.05).However,there was a significant difference on the 7th day compared with that of hospitalization day(P<0.05).On the 7th day,the treatment group was more effective than the control group in reducing the MCTSI score(P<0.05).10.Comparison of patients' first time of spontaneous defecation and farting,abdominal pain relief,and length of hospitalization: Patients in the treatment group had the first time of spontaneous defecation and farting,abdominal pain relief time,and length of hospital stay shorter than those in the control group(P<0.05).Conclusion: 1.Chai Huang Qing Yi Huo Xue Granule and basic treatment can significantly ameliorate disease symptoms,physical signs,serum amylase,white blood cell count,calcium ion,APACHE II score,BISAP score,MCTSI score of SAP paitient and shorten the patient's first spontaneous defecation and farting time,abdominal pain relief time,and length of hospitalization.Chai Huang Qing Yi Huo Xue Granule can improve the clinical regression of severe acute pancreatitis.2.The efficacy of the treatment group was better than that of the control group in terms of overall effective rate,symptomatic quantification score,physical signs quantification score,white blood cell count,APACHE II score,BISAP score,MCTSI score,patient's first time of spontaneous defecation and farting,abdominal pain relief time,and hospitalization days,suggesting that the efficacy of Chai Huang Qing Yi Huo Xue Granule in patients with severe acute pancreatitis is better than Qing Yi Li Dan Granule. |
PDF Full Text Request