| Objective:The purpose of this study is to investigate the effect of acupuncture at Shenting and Baihui on memory dysfunction in post-stroke,and to explore its possible central mechanism by resting state functional magnetic resonance imaging(fMRI),so as to provide scientific evidence.Methods:30 patients with memory dyfunction after apoplexy were randomly divided into the treatment group and the control group according to 1:1.The two groups were consistent in basic treatment.The treatment group treated by acupuncture at Shenting and Baihui combined with cognitive rehabilitation training.The control group received cognitive rehabilitation training,30min per day,1 times a day,5 days a week,4 weeks for a course of treatment for 12 weeks.Before and after the intervention of two groups,the subjects were scanned by resting fMRI(functional Magnetic Resonance Imaging,fMRI)and evaluation of Wechsler Memory Scale(WMS-RC),meet the evaluation scheme set using independent sample T test and non-parametric Wilcoxon test to compare the two groups,using the amplitude of low-frequency fluctuation(ALFF)calculate the zALFF(ALFF after Z transformation)value of the difference brain area between the treatment group and the control group before and after the intervention.Using the partial correlation analysis,which age,education level and course of disease as covariate,to analysis the correlation between the zALFF value of different brain and WMS-RC scores.Results:1.There were no significant differences between treatment group and control group in age,education level,and the daily life ability(P>0.05).There was no significant difference in the scores of WMS-RC(P>0.05).2.The difference between the treatment group and the control group before and after treatment was compared.The results showed that the total score of WMS-RC,the long-term memory and the short-term memory score in the treatment group were significantly different from those in the control group(P<0.05).There was no significant difference in the scores of WMS-RC(P>0.05).3.The changes in the zALFF value before and after the treatment were compared in two groups,and the age,education and course of the two subjects were covariate,the right parietal lobule,the left posterior cingulate gyrus,right frontal gyrus,right middle temporal gyrus,right inferior frontal gyrus and right posterior central gyrus was significant different between the two groups(P<0.05)4.Using the partial correlation analysis,which age,education and course of disease as covariate,to analysis the correlation between the zALFF value of different brain and WMS-RC total score,long term memory and short-term memory in WMS-RC scale.The zALFF value of right middle frontal gyrus positively correlated with the total score of WMS-RC and the short-term memory(r=0.537,0.479;P<0.05),The zALFF value of right inferior parietal lobule was positively correlated with the total score of WMS-RC(r=0.505,P<0.05);The zALFF value of left posterior cingulate also showed positively correlated withlong term memory(r=0.424,P<0.05)Conclusion:1.Acupuncture of Shen Ting and Baihui along with cognitive training can improve the whole memory function,short-term memory and long term memory more than cognitive training group of stroke patients.2.The mechanism of improving whole memory function of stroke patients by Acupuncture of Shen ting and Baihui along with cognitive training may be related to the righ inferiort parietal lobe and right middle frontal gyrus.The mechanism of improving long-term memory function may related to left posterior cingulate.The mechanism of improving short-term memory function may related to right middle frontal gyrus. |
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