Fractional Amplitude Of Low Frequency Fluctuations And Gray Matter Volume On Patients With Depressed Bipolar Disorder

ObjectiveUsing fractional amplitude of low frequency fluctuations(fALFF)and gray matter volume(GMV)joint to explore the mechanism of brain function and structure in patients with bipolar disorder(BD),then we combined with clinical symptoms,cognitive function(neuropsychological test)to further explore the disease mechanism of bipolar disorder.The research can provide theoretical basis for biological mechanism and the development of neuroimaging in BD.Methods30 bipolar depressed patients and 31 healthy subjects demographically matched with the BD group.After high-resolution structural and rs-fMRI scanning,Data Processing and Analysis for Brain Imaging(dpabi)and SPM8 were used to find potential differences in fALFF and GMV between the two groups.A Pearson correlation model was used to analyze associations of functional and morphometric changes with clinical symptoms and cognitive tests.A GRF(p<0.05)theory for multiple comparison correction.Results(1)fALFF: compared to healthy controls,BD group had significant lower fALFF values in the lingual gyrus and increased fALFF values in the bilateral superior frontal gyrus and left superior frontal gyrus(2)GMV: patients with BD showed significant GMV decrease in the bilateral superior temporal gyrus,bilateral superior frontal gyrus,right superior frontal gyrus,right parahippocampa gyrus and precuneus(3)Association between functional and structure results: in this study,we found the overlap of brain regions focus on left SFG.(4)Correlations with clinical variables: The structural and functional brain alterations in BD did not significantly correlate with symptom severity in the patient group.However,significant negative correlations were observed between abnormal GMV values in left SFG and vocabulary memory,as abnormal GMV values in precanues and delayed memory was,and positive correlations between abnormal GMV values in left SFG and verbal function.ConclusionsBased on the method of brain imaging analysis of bipolar disorder,this study found the corresponding abnormal brain regions from two aspects of function and structure,involving the LCSPT loop.More importantly,superior frontal gyrus was the most robust and reliable abnormality,as an overlap of both structure and functional MRI were found,which played an important role in pathology in BD.