The Study Of Efficacy Of Antler Gelatin/Deerhorn Glue In The Treatment Of Hypoplasia Of Uterus

Objective:To observe the effect of lujiaojiao on the development of uterine dysplasia in mice and rats with uterine dysplasia and its effect on the uterine development of normal young mice and rats.To analyze the effect of lujiaojiao on the development of uterine dysplasia,and to reveal the development of uterine dysplasia the mechanism of efficacy.Method:The corresponded drugs were given to the normal young mice for 14 days.The levels of estradiol?E2?,luteinizing hormone?LH?,follicle stimulating hormone?FSH?in the serum of normal young mice were measured and the wet weight and organ index of the thymus,spleen and uterus were calculated.Progesterone?PROG?and estrogen receptor?ER?in the uterus.Used the bilateral bilateral opening,respectively,100%of the ovaries were removed method of replication of mouse uterine dysplasia model,continuous fed the corresponded drugs for 14 days.The levels of E₂,LH,FSH,PROG and uterine ER in the serum of uterine dysplasia mice were measured and the wet weight of the thymus,spleen and uterus were calculated and the corresponding organ index was calculated.Used the bilateral bilateral opening,70%of the ovaries were removed by copying the mouse uterine dysplasia model,continuous fed the corresponding drugs for 14 days.The levels of E₂,LH,FSH,PROG and uterine ER in the serum of uterine dysplasia mice were measured by measuring the wet weight of the thymus,spleen and uterus of the mice and calculating the corresponding organ index.The corresponded drugs were given to the normal young rats for 14 days.The levels of E₂,LH,FSH,PROG and uterine ER in serum of normal young mice were measured and the wet weight of the uterus was measured and the corresponding organ index was calculated.The uterine dysplasia model was reproduced by the method of resection of 70%ovary on both sides.Continuous administration of the corresponding drugs for 14 days.The levels of E₂,LH,FSH,PROG and uterine ER in serum of rats with uterine dysplasia were measured by measuring the wet weight of the thymus,spleen and uterus of the rats and calculating the corresponding organ index.Result:Compared with the blank group,the lujiaojiao group could increase the organ index and the expression of ER in the thymus,spleen and uterus of the normal young mice.The contents of E₂ and PROG in the serum were significantly increased,the FSH and LH contents were decreased,Can promote the development of the uterus.The levels of E₂ and PROG in serum were significantly decreased and the levels of FSH and LH were significantly decreased in the model group,and the expression of ER and UG in the uterus and uterus were significantly lower than those in the control group The Antler can increase the expression of ER and PROG in serum,decrease the content of FSH and LH,and improve the uterus,thymus,spleen,pituitary,hypothalamic tissue lesions..Compared with the blank group,the antler group could increase the organ index and the expression of ER in the thymus,spleen and uterus of normal young rats.Can make the serum E2 and PROG content significantly increased,reduce serum FSH,LH content,promote the development of the uterus.The expression of E₂ and PROG in the serum of the thymus,spleen and uterus of the model group and the uterine ER were significantly decreased,and the levels of FSH and LH were significantly decreased in the model group,indicating that the ovariectomized rat uterine dysplasia model copy successful.Lujiaojiao can improve the rat thymus,spleen,uterine organ index and uterine ER expression;can make serum E₂ and PROG content increased,FSH and LH content decreased;also can improve the uterus,ovaries,thymus,Spleen,pituitary,hypothalamus lesions.Conclusion:Suggesting that lujiaojiao through the improvement of uterine dysplasia estrogen levels caused by the decline in symptoms,restored the thymus,spleen,uterine index,corrected uterine dysplasia of the mouse's internal environment.At the same time can significantly or significantly improve the uterus,ovaries,thymus,spleen,pituitary and other tissue lesions.Effectively alleviate the symptoms of uterine dysplasia.