The Correlation Analysis Of Thyroid Function Level And Large Vascular Disease In Patients With Type 2 Diabetes Mellitus

Objective:The purpose of this paper is to explore the relationship between thyroid function and the correlation of major vascular lesions in newly-diagnosed T2 DM,evaluation of different levels of thyroid function of complications related to diabetes,further clarify the importance of the management of thyroid function in patients with diabetes.Methods:208 cases with newly diagnosed T2 DM patients were collected in November2016-March 2018 in our hospital endocrinology inpatient or outpatient,all the patients were in accordance with the 1999 world health organization(WHO)diagnostic criteria for type 2 diabetes.Patients with thyroid hormone abnormalities(mainly low FT3 syndrome,hyperthyroidism and thyroidectomy),the absence of thyroid related antibodies and related complications were removed,finally,a total of161 newly diagnosed T2 DM patients were selected.Of TSH stratification: <2.5 mIU/l divided into group A,2.5-4.2 mIU/l for group B,>4.2 mIU/l for group C,analysis of thyroid function level of first diagnosis in patients with T2 DM patients with the biochemical indicators(FPG,TG,TC,HbAlc,TSH,TGAb,TPOAb,CIMT,etc.)and the influence of large vascular lesions,and analyze the correlation between TSH and his index.Results:1.It was found that men's fasting blood glucose,high-density lipoprotein,uric acid and creatinine were all higher than females,and the difference was statistically significant(P<0.05)by gender groups.The positive rate of arterial plaque in lower extremity was 14.9%(24cases)and 9%(6cases),and the difference was statistically significant(P=0.006).The positive rate of carotid artery plaques was 38.3%(70 cases)and 15.6%(28 cases),and the difference was statistically significant(P=0.005).The risk of concurrent hypertension was also significantly higher in men than in women,with 39.4% in men and 13.4% in women,and statistically significant difference(P=0.001).2.Comparison between groups of subclinical hypothyroidism group(group C)of triglyceride,total cholesterol,common carotid artery intima-media thickness were higher than group A and group B,and the difference was statistically significant(P<0.05);The high-density lipoprotein in group C was lower than group B,and the difference was statistically significant(P<0.05).The low density lipoprotein in group B and C was higher than group A,and the difference was statistically significant(P<0.05).Fasting blood glucose and glycosylated hemoglobin C were higher than those in the other two groups,but the difference was not statistically significant(P>0.05).3.Comparison between the three groups found that with the increase of TSH,TGAb positive rate also will increase,and the difference was statistically significant(P<0.05),although found no statistically significant difference,the positive rate of diabetes mellitus and thyroid peroxidase antibody in subclinical hypothyroidism group was still higher than that of group A and group B.Conclusion:1.The TSH level of the patients was closely related to the thickness of the blood lipid and carotid artery and the large vascular lesions.When TSH>4.2 mIU/l,the risk of large vessel lesions increased.2.In newly diagnosed T2 DM,the incidence rate was 11.2%,and the positive rate of thyroid hormone antibody(TGAb and TPOAb positive)was 13.7%.Routine screening of thyroid hormones and associated antibodies in T2 DM patients is necessary.