Clinical Observation Of Thyoid Function Condition In Newly Diagnosed Type 2 Diabetes

Objective: To analyse the difference of thyroid function and TRAb in the thyroid disease of patients with newly diagnosed type 2 diabetes. To further study the clinical feature between diabetes and thyroid disease through the analysis of the changes of thyroid hormones level and relative elements in newly type 2 diabetes patients. To explore the clinical significance of thyroid function in newly type 2 diabetes patients.Methods:To select 150 newly diagnosed T2 DM Patients who stayed in the Endocrinology department and outpatient of First People’s Hospital of Xingtai City from June in 2013 to June in 2014, and select 100 healthy people from as control group in the same period of time. All the people were on an empty stomach for 8 hours. We tested T3, T4, TSH, FT3, FT4, TRAB.Write ages, sex, body, weight, height and BMI.To take 12 ml enous blood from newly diagnosed T2 DM, from which we take 5ml to test C-peptide; from which we take 7ml to test Hb Alc, FBG, PBG, TC, TG, HDL-C, LDL-C by the biochemical analyzers. To Collect 10 ml of the morning cleaning middle urine to test microalbuminuria by the biochemical analyzers. To establish data base by Microsoft Excel. To apply SPSS21.0 to analyze the data. To illustrate all the measurement data by x±s and test the distribution of the variables. To analysis the enumeration data by chi-square, and enumeration data with homogeneity by Single factor variance, and not enumeration data with homogeneity by Tamhane’s T2.Results:1 The comparison of thyroid function and autoantibody between newly diagnosed T2 DM and control group.Among 150 patients in newly diagnosed T2 DM, thyroid function were abnormal 44 patients(29.33%), positive TRAb were positive in 22 patients(14.67%). abnormal thyroid function were tested in 9 of the healthy people, 6 of which tested positive TRAb. To compare the rate of abnormal thyroid function and positive TRAb in the group of T2 DM, higher than those in the control group(P<0.05).2 The constitue features of abnormal thyroid function in newly diagnosed T2 DM group.The number of abnormal thyroid function was 44 in 150 patients in newly diagnosed T2DM; To find the number of low T3 syndrome were 18(12.00%). To find the number of subclinical hypothyroidism were 18(12.00%). To find the number of clinical hypothyroidism were 4(2.67%); To find the number of subclinical hyperthyroidism were 4(2.67%). low T3 syndrome and subclinical hypothyroidism were main in abnormal thyroid function in newly diagnosed T2 DM group.3 The sex difference of subclinical hypothyroidism and rate of TRAb in newly diagnosed T2DMIn newly diagnosed T2 DM, we find number of subclinical hypothyroidism were 18, of which male were 5(6.67%), female were 13(17.33%), The female are obviously more than males, the statistics was significant(P<0.05).In newly diagnosed T2 DM, the number of the rate of positive TRAb were 22, of which male were 6(9.33%), female were 16(20.00%), The female are obviously more than males, the statistics was significant(P<0.05).4 The clinnical features of different thyroid function in newly diagnosed T2DMCompare the low T3 syndrome, subclinical hypothyroidism, normal thyoid function in the patient in newly diagnosed T2DM:To find higher glycosylated hemoglobin in Low T3 syndrome group, not in normal thyroid function group, the statistics was significant(P<0.05).To find higher FBG、PBG in Low T3 syndrome group,not in subclinical hypothyroidism and normal thyoid function, the statistics was significant(P<0.05). the statistics was not significant between subclinical hypothyroidism and normal thyoid function.To find lower C-peptide in low T3 syndrom, not in subclinical hypothyroidism and normal thyoid function, the statistics was significant(P<0.05), the statistics was not significant between subclinical hypothyroidism and normal thyoid function.To find higher LDL in subclinical hypothyroidism, not in low T3 syndrom and normal thyoid function, the statistics was significant(P<0.05). The statistics was not significant between low T3 syndrom and normal thyoid function.The statistics was not significant in age, BMI, TC, TG, HDL, um ALB among the three groups.Conclusions:1 Abnormal thyroid function in patients with newly diagnosed type 2 diabetes prevalence and TRAb positive rate were significantly higher than healthy people.2 Thyroid dysfunction in newly diagnosed type 2 diabetic patients mainly manifested as subclinical hypothyroidism and low T3 syndrome. There is gender difference in sub clinical hypothyroidism, and women significantly outnumber men, not for low T3 syndrome.3 The level of glucose is highest the group of low T3 syndrome in newly diagnosed type 2 diabetes patients.4 Lipid metabolism disorder of subclinical hypothyroidism is heavier in newly diagnosed type 2 diabetes patients.