Analysis Of Related Risk Factors Of Cerebral Microbleeds In Patients With Ischemic Stroke

Objective: We aim to investigate the incidence of CMBs in patients with acute ischemic stroke and the association between cerebral microbleeds and its risk factors.Methods: We retrospectively examined 218 patients with acute ischemic stroke who consecutively were admitted to the First Hospital of Chen zhou from July 2015 to December 2016.All patients underwent standardized clinical assessment and cerebral MRI(including general sequencing and susceptibility-weighted imaging).According to the presence of CMBs in susceptibility-weighted imaging),all the patients were classified into two groups: with CMBs positivity of 89 cases and negtivity of 129 cases.Patients' characteristics were summarized for each group separately.Messages including(age,sex,height,weight,medical history and history of drug use),laboratory data including(serum lipid fractions and creatinine)and radiologic results were achieved.Then,we did statistical comparison between two groups and multivariable logistic regression to identify the relative risk factors.Results:1.According to achieved data from 218 patients with acute ischemic stroke,we found that there were 89 patients CMBs positivity and the prevalence of CMBs was 40.8%.There were 51 cases on stage 1(CMBs number 1-3),accounting for 23.4% in CMBs positive group;24 cases on stage 2(CMBs number 4-10),accounting for 27% in CMBs positive group;14 cases on stage 3(CMBs number >10),accounting for 15.7% in CMBs positive group.2.In our study,there were totally 428 CMBs in 89 cases with CMBs positivity group.The incidence of CMBs in the basal ganglia and thalamus was high,accounting for 52.8%,followed by brain stem/cerebellar,accounting for 27.2%,and the least common site was in the lobar region,accounting for 20%.3.Comparisons between 89 cases with CMBs positive and 129 cases CMBs negative groups,there were statistically difference(P <0.05)in age,hypertension,obesity,impaired kidney function,serum total cholesterol ? high-density lipoprotein cholesterol,leukoaraiosis,and anti-platelet therapy.There were no significant difference in sex,smoking,diabetes,triglycerides and low-density lipoprotein cholesterol.4.Considering patients with or without CMBs as dependent variable,multivariate logistic regression analysis was used to identify age,hypertension,obesity,impaired kidney function,serum total cholesterol,high-density lipoprotein cholesterol,leukoaraiosis and Anti-platelet therapy,the results revealed that age(OR=3.152,95%CI 1.946-5.106,P =0.000),hypertension(OR=2.602,95%CI 1.220-5.550,P =0.013),obesity(OR=3.035,95%CI 1.496-6.158,P =0.002),impaired kidney function(OR=2.836,95%CI 1.254-6.418,P =0.012),leukoaraiosis(OR=6.792,95%CI 2.597-17.760,P=0.000)were independent risk factors of the incidence of CMBs.Conclusion:1.The incidence of CMBs in patients with acute ischemic stroke was high and the location was mainly concentrated in the basal ganglia / thalamus and infratentorial areas.2.Independent risk factors for cerebral microbleeds in patients with acute ischemic stroke include age,obesity,hypertension,renal impairment,white matter lesions.Anti-platelet therapy was not the Independent risk factors of CMBs.