| Background:MicroRNAs are present in human plasma and have been reported to be biomarkers for cardiovascular diseases.The aim of this study was to investigate the value of circulating microRNA-208b(miR-208b)for the diagnosis and prognosis of acute myocardial infarction(AMI).Methods:A total of 100 AMI patients,80 unstable angina(UA)patients,and 80 healthy controls(HCs)were consecutively included in this study.Plasma was collected from each participant on admission,and the levels of circulating miR-208b were measured using real time-quantitative polymerase chain reaction(qRT-PCR).The AMI patients who underwent percutaneous coronary intervention(PCI)were followed up at 6 months post-AMI.Results:The concentration of miR-208b were higher in the AMI patients than in the other two groups(p<0.05);and it was positively correlated with the levels of creatine kinase(CK)-MB and cardiac troponin I(cTnI)(p<0.01).Moreover,the receiver operating characteristic(ROC)curves showed that miR-208b was sensitive like CK-MB and cTnI for the diagnosis of AMI.In addition,the miR-208b concentration in AMI patients with three-vessel coronary artery disease(CAD)was higher than that of single-or two-vessel CAD AMI patients(p<0.05).Also,the miR-208b expression after PCI was significantly lower than on admission(p<0.01).Furthermore,miR-208b expression in AMI patients with left ventricular remodeling/MACEs was higher than in those without after PCI(p<0.05).Conclusions:Circulating miR-208b may serve as a sensitive biomarker for the diagnosis and prognosis of AMI patients. |
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