Expression And Significance Of Tumor Stem Cell Related Markers CD44+/CD24-/Low And ALDH1+ In Triple Negative Breast Cancer Tissues

Objective:Investigating the expression of aldehyde dehydrogenases 1（ALDH1）and CD44^+/CD24^-/low in triple negative breast cancer（TNBC）tissues and its relationship with prognosis of triple negative breast cancerMethods:Immunohistochemistry was used to detect the express of ALDH1 and CD44+/CD24-/low in formalin-fixed paraffin-embedded（FFPE）tissue samples of triple negative breast cancer.Student t test and Pearson’s chi-square was used to analyze the expression of aldehyde dehydrogenases L（ALDH1）and CD44⁺/CD24^-/low/low in triple negative breast cancer（TNBC）tissues and its relationship with prognosis of triple negative breast cancer.Results:The expression rate of ALDH1+in TNBC tissues was（14）46.67%,and the expression rates of CD44⁺/CD24^-/low were（17）56.67%.The expression rate of ALDH1+,and the positive rate of CD44⁺/CD24^-/low expression in non-triple negative breast cancer tissues was（5）16.67%,and（8）26.67%,respectively.The positive expression rates of ALDH1 and CD44+/CD24-/low in TNBC tissues were significantly higher than those in non-triple negative breast tissues.The local recurrence and distant metastasis rates of patients with CD44⁺/CD24^-/low and ALDH1（+）group were significantly higher than those of other three negative breast cancer patients.Conclusions:Overexpression of ALDH1+and CD44+/CD24-/low in TNBC tissues is an independent risk factor for prognosis in TNBC patients,and is involved in the regulation of TNBC occurrence and prognosis.