The Viral Etiology And The Analysis Of Clinical Features In Children With Community-acquired Pneumonia In Soochow Area, 2010?2014

Objective: To expand our understanding of the viral epidemiology in children with community-acquired pneumonia in Soochow area.Compare clinical characteristics and blood routine examination results between respiratory syncytial virus infection alone group,HBoV infection alone group and parainfluenza virus type 3 infection alone group.To help the early diagnosis and treatment of community-acquired pneumonia.Methods: 22825 nasopharyngeal secretion samples were collected from hospitalized children with community-acquired pneumonia,admitted from January 2010 to December 2014,we tested respiratory syncytial virus,influenza A and B,parainfluenze virus 1 to 3,and adenovirus by direct fluorescent antibody test.These specimens also were assayed for HBoV by polymerse chain reaction(real-time PCR/real-time fluorescence quantitative PCR).The information of population profile,clinical feature and peripheral blood text of the CAP patients were retrospectively collected by charts review with standard questionnaire,and the data was analyzed by descriptive statistical methods.Results:(1)From 2010 to 2014,per annum virus detection positive rate of 24.04%?35.99%?28.75%?22.57%?27.54%.Of the 22825 nasopharyngeal secretion samples,6314(27.66%)patients had evidence of virus infection.Among them,4437cases(19.44%)were RSV infection,1431 cases(6.27%)were HBoV infection,1145 cases(5.02%)were Pinf3 infection,439 cases(1.92%)were InfA infections,218 cases(0.96%)were ADV infections,151 cases(0.66%)were Inf B infections,141 cases(0.62%)were Pinf1 infections,and last,3 cases(0.01%)were Pinf2 infections.(2)In different seasons,the kinds of common viral pathogens are different.The epidemic season of RSV was autumn and winter,HBo V was summer and autumn,Pinf3 was summer.ADV,Pinf1,InfA and InfB distributed throughout the year.Pinf2 sporadic throughout the year.(3)The highest infection rate of single RSV,HBoV and Pinf3 infection occurred among the children under 24 months of age.For specifically,RSV infection rate was highest among the children under 3 months of age,HBoV infection rate was highest among children of 6months ~24 months of age,parainfluenza virus type 3 infection rate was highest among children 6months ~12 months of age.(4)Among the groups of single RSV infection,single HBoV infection and single Pinf3 infection,fever occurred more frequently in children with single HBoV infection.,the incidence rate of HBo V(55.61%)was greater than the incidence rate of Pinf3(44.19%),then followed by the incidence rate of RSV(30.32%),the difference of incidence rates between the three groups is statistical significant.Wheezing and polypnea were more likely to occurred in children with RSV simple infection than HBoV and Pinf3,the difference between them is significative.Moist rale was less occurred in children with Pinf3 single infection(39.09%)than HBoV(48.72%)and RSV(54.15%),the difference between them is statistical significant.On laboratory studies,the median account of white cell,the ratio of neutrophilic granulocyte of the HBoV infection alone group were higher than that of RSV infection alone group and Pinf3 infection alone group.The difference between RSV infection alone group and Pinf3 infection alone group is not statistical significant.Conculsion: RSV,HBoV and Pinf3 are the most common viral pathogens of CAP in children in Soochow area.In different seasons and different ages,the clinical manifestations and peripheral blood text of viral pathogens are statistical different.Uderstanding the viral epidemiology and the analysis of clinical features and peripheral blood routine examination in children with community-acquired pneumonia in Soochow area to help the early diagnosis and treatment of community-acquired pneumonia.