A Meta-analysis Of Dietary Factors And Vitamin On Liver Cancer

Objectiveto explore the potential between dietary factors and Chinese people with liver cancer,To analyze the relationship between vitamin intake and the risk of liver cancer by a meta-analysis,In order to reduce the incidence of liver cancer and try to provide scientific evidence for prevention and management of the disease.Contents and methods?1?The CNKI,WanFang,VIP,China Biology Medicine disc,Embase,Science direct,Embase and Medline databases were searched.We searched and selected Chinese and English literatures on dietary factors and liver cancer from the inception to December 2016.Statistical analysis was conducted using Stata12.0,Cochrane's Q and I²statistics were used to evaluate heterogeneity among studies,subgroup analysis and sensitivity analysis were used to explore the heterogeneity sources.Publication bias was calculated by Begg rank correlation test and Egger linear regression test.?2?The CNKI,WanFang,VIP,China Biology Medicine disc,Embase,Science direct,Embase and Medline databases were searched.We searched and selected Chinese and English literatures on vitamin and liver cancer from the inception to December 2016.Statistical analysis was conducted using Revman5.0,Cochrane's Q and I²statistics were used to evaluate heterogeneity among studies,subgroup analysis and sensitivity analysis were used to explore the heterogeneity sources.Publication bias was calculated by Begg rank correlation test and Egger linear regression test.Using Stata13.0 analysis to Begg rank correlation method and Egger regression method is used to quantitatively identify the publication biasResult?1?We identified 72 eligible studies which involved 16439cases of liver cancer and 40816 cases in control group.The pooled OR values?95%CI?of shallot or garlic,bean products,vegetables,fruits,teas and fishes were all under 1,The results of OR and 95%CI are as follows:shallot or garlic?OR 0.46,95%Cl 0.33 to 0.64?,bean products?OR0.64,95%Cl 0.45 to 0.92?,vegetables?OR 0.48,95%Cl 0.31 to 0.75?,fruits?OR 0.45,95%Cl 0.42 to 0.70?,teas?OR 0.41,95%Cl 0.30 to0.57?and fishes?OR 0.75,95%Cl 0.62 to 0.90?;the pooled OR values?95%CI?of dry hard foods,high salt diet,eggs,mildew foods,smoked foods,pickled Foods,wine,fat meat and eating raw fish were all greater than 1,The results of OR and 95%CI are as follows:dry hard foods?OR2.72,95%Cl 1.90 to 3.91?,high salt diet?OR 1.68,95%Cl 1.13 to 2.51?,eggs?OR 1.87,95%Cl 1.42 to 2.46?,Mildew foods?OR 1.83,95%Cl 1.57to 2.14?,smoked foods?OR 1.55,95%Cl 1.29 to 1.87?,pickled Foods?OR 2.78,95%Cl 2.11 to 3.665?,wine?OR 2.14,95%Cl 1.81 to 2.54?,fat meat?OR 2.23,95%Cl 1.80 to 2.75?and raw fish?OR 3.74,95%Cl 1.78to 8.84?;There was no significant correlation between animal meat,fried food,acid and vinegar foods and liver cancer.?2?A total of 9 articles were included,with the total vitamin RR value and 95%Cl:0.82,0.69-0.98,P<0.05,Subgroup analyses indicated that the RR was 0.85,95%Cl?0.75-0.96?,P=0.000 in cohort study group and the RR was0.60,95%Cl?0.37-0.98?,P=0.000 in case-control study;The RR was0.77,95%Cl?0.62-0.94?,P=0.000 for Intake of vitamin E and the RR was0.69,95%Cl?0.54-0.89?,P=0.000 for Intake of folic acid;Vitamin A and vitamin C were not statistically significant in the subgroup analysis?0.89,95%Cl?0.55-1.44??0.99,95%Cl?0.83-1.19??0.84,95%Cl?0.49-1.43??;According to the results of the analysis of the solubility of vitamins,the intake of fat-soluble vitamins could reduce the risk of liver cancer:RR=0.79,95%Cl?0.66-0.94?;water-soluble vitamins were not statistically significant:RR=0.84,95%Cl?0.59-1.19?.Conclusion?1?Allium,vegetables,bean Products,vegetables,fruits,teas and fishes may be protective factors of liver cancer among Chinese people,while rough foods,high salt diet,eggs,moldy foods,smoked foods,pickled foods,wine,fat meats and raw fishes are risk factors.Liver cancer association with animal meat,fried foods and vinegar foods is uncertain yet.?2?Vitamin?A,C,D,E,Folic acid?intake may reduce the risk of liver cancer,especially vitamin E,folic acid to reduce the risk of liver cancer is more significant,vitamin may be a protective factor for liver cancer.