| Objetive Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of insulin resistance (IR) and metabolic syndrome (MS). It has emerged as a serious public health burden with its rising prevalence and the more understanding of it. This study systematically evaluated the correlation between nonalcoholic fatty liver disease and vitamin D levels in Chinese population.Methods We searched PubMed, CNKI, VIP, Wanfang and Duxiu databases to identify all clinical studies that assessed the association between NAFLD and vitamin D up until March 2016. At the same time, the conference papers related to the set and the reference of the included review were manually searched. we screened literatures according to the inclusion and exclusion criteria. Pooled standardized differences, heterogeneity, bias estimation and sensitivity were analyzed using software stata11.0.Results 11 original studies including case-control study and cross-sectional study were selected in the study, totally 3752 cases of NAFLD and 5360 cases of non-NAFLD. Fatty liver were all diagnosed by abdominal ultrasound. Meta analysis showed that, compared with the control group, the level of 25(OH)D in NAFLD patients was decreased, SMD:-0.34ng/ml, 95%CI:-0.49, -0.18 (P=0.000), the difference was statistically significant. When conducted subgroup analysis according to different study type, sex and the severity of fatty liver, the results showed that 25(OH)D decreased in NAFLD patients both in case-control study and cross-sectional study (both P<0.05).Ignored sex, male and female NAFLD patients had lower 25(OH)D when compared with the healthy (P<0.05). And 25(OH)D decreased with the severity of fatty liver(P < 0.05). The sensitivity analysis of each study was stable, and there was no significant publication bias.Conclusion The level of 25(OH)D in NAFLD patients was significantly lower than controls, and 25(OH)D decreased with the severity of fatty liver. |
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