The Study Of Angptl-2 And IL-6 Expression In Patients With Acute Coronary Syndrome

Background: Inflammation is implicated in several stages of coronary heart disease(CHD)development,including atherosclerosis,plaque destabilization,plaque rupture and post-ischaemia damage to the myocardium.Histologic characteristics of vulnerable plaques include a lipid-rich core with a thin fibrous layer and infiltration with inflammatory cells near the fibrous cap.ACS is a dangerous disease.Acute coronary syndrome(ACS)remains a major cause of morbidity and mortality worldwide.The primary causal factor responsible for the majority of acute coronary events is an acute atherothrombotic event resulting from disruption of vulnerable plaques.If the biochemical markers of vulnerable plaques can be discovered by noninvasive means,the clinical diagnosis of ACS can be simplified and the early prevention and control becomes possible.Angptl-2,IL-6 are regarded as a proinflammatory factor.A number of studies have shown that angiopoietin-2(Angptl-2)and interleukin-6(IL-6)are involved in the development of CHD.Objective: To explore the correlation between serum Angptl-2,IL-6 level and coronary lesions severity in patients with CHD and the predictability of ACS.Methods: This prospective,single-centered study was carried out by the Department of Cardiology,LOUDI Centre Hospital from January 2016 to January 2017.A total of 159 patients were recruited and assigned to three groups according to their clinical condition and angiography findings.41 had stable angina pectoris(SAP)and 78 had ACS.An additional 40 individuals with typical chest pain but normal coronary artery angiograms were considered as the control group.Results:1.Serum Angptl-2 and IL-6 levels were significant higher in patients with SAP than in those with control.[(23.67±3.42 VS 10.66±5.72ng/ml,p<0.05),(30.98±9.42 VS 22.16±7.06pg/ml,p <0.05)].2.Serum Angptl-2 and IL-6 levels were significant higher in patients with ACS than in those with stable angina.[(32.88±4.06 VS 23.67±3.42 ng/ml,p <0.05),(42.26±8.76 VS 22.16±7.06 pg/ml,p <0.05)].3.Compared with single lesion group,the Angptl-2 and IL-6 levels of double levels increased more significantly;[(35.99±3.70 VS(22.67±2.65ng/ml,p<0.05),(41.93±6.02 VS 35.98±5.26pg/ml,p <0.05)];Compared with double lesion group,the Angptl-2 and IL-6 levels of multiple levels increased more significantly.[(40.49±3.57 VS 35.99±3.70ng/ml,p<0.05),(45.95±5.06 VS 41.93±6.02 pg/ml,p <0.05)].4.In the CHD group,Serum Angptl-2 was positively correlated with IL-6(r=0.645,p<0.05),Serum Angptl-2 was positively correlated with CK-MB(r=0.424,p<0.05),Serum Angptl-2 was positively correlated with and TnI(r=0.562,p<0.05);Serum IL-6 was positively correlated with CK-MB(r=0.313,p<0.05),Serum IL-6 was positively correlated with and TnI(r=0.478,p<0.05).Conclusions:1.With the severity of coronary artery disease increased,serum levels of Angptl-2,IL-6 increased,suggesting that Angptl-2,IL-6 can indirectly reflect the severity of coronary artery disease;2.In the CHD,Angptl-2 was positively correlated with IL-6,suggesting that Angptl-2 may have synergistic effect with IL-6;3.Angptl-2 and IL-6 may be predictors of ACS.