Study On The Improvement Of Constipation In Hemodialysis Patients By Oral Probiotics

Constipation may induce the cardiovascular disease,which will be harmful to human health.The oral probiotics tablets will improve the intestinal flora and fatty acids metabolism,which will give great study significance for improving the constipation of maintained-hemodialysis patients.The large amount of Lactobacillus and Bifidobacterium existed in the intestinal tract symbolize the healthy intestinal tract.Therefore,the study on the protection of intestinal tract by Lactobacillus and Bifidobacterium becomes the focal points.The Lactobacillus Paracasei L9,Lactobacillus Acidophilus A5,Bfidobacterium A6 and Lactobacillus Rhamnosus LGG are selected as the probiotics tablets used in this study.Twenty experiment objects are studies on the constipation.The data is collected by questionnaire about defecation.It uses the methods of data analysis on feces classification,feces pH and feces water content.The research result indicates that the exertion in defecation is reduced from 11 cases to 5 cases in the intervention period of V2 and V6,and reduced to 3 cases in the intervention period of V6.The unfinished feeling of defecation is significantly reduced from 18 cases to 3 cases.The number of people with constipation is just 2 cases.These three indexes are significantly reduced.The content of acetic acid and propionic acid in the intervention period of V2 is significantly increased.The content of acetic acid is increased from 1.77±1.30 to the 3.72±3.31 in the period of V2.The content of propionic acid is increased from1.47±1.49 to the 2.63±2.28 in the period of V2.The content is reduced in the intervention period of V6,but it is still increased by comparing with the baseline period of V0.It indicates that the probiotics can improve the feeling of the patients and make them feel relax.The feeling of patients will be better than before the intervention.However,it has no significant differences on the change of the feces PH and feces water content.Twenty experiment objects are studies on the constipation with the method of the measurement of feces short chain fatty acids and 16 s high-throughput sequencing.The research result indicates that the Bifidobacterium is reduced to 3.82% in the intervention period of V2,but the streptococcus and roseburia stanton and savage are increased.In the intervention period of V6,the Bifidobacterium is increased to 6.98%,the enterococcus is increased to 6.59%,the streptococcus is continuous to be increased to 2.43% and the megamonas shah and collins is increased to 1.02%.The oral probiotics tablets for 6 months will have continuous effect on the constipation,short chain fatty acids and intestinal flora.Dobacterium in V6 was increased to 6.98%,Enterococcus was up to 6.59%,Sstreptococcus was up to 2.43%,and the Genus Monocytosis increased to 1.02%.The effects of long-term oral probiotic tablets on constipation effect and short chain fatty acids and intestinal flora in six months were continuously affected.