Expression Of Transaldolase (TAL) In Non-small Cell Lung Cancer And Its Clinical Significance

Objective: We collected tumor tissues samples and para-carcinoma tissues of primary non-small cell lung cancer(NSCLC).Immunohistochemistry was used to investigate the expression of transaldolase in non-small cell lung cancer(NSCLC)and its clinical significance.Methods: We collected 69 cases of primary non-small cell lung cancer patients with postoperative tumor tissue specimens and para-carcinoma tissue specimens.As soon as the tumor was cut from the tumor tissue samples to send frozen sections were diagnosed as non-small cell lung cancer,then take tumor tissue specimens and para-carcinoma tissue specimens to the formalin immersion fixed,and then paraffin embedded preservation.We recorded patient-related clinical and pathological data,such as name,sex,age,lymph node metastasis,pathologic type,degree of tumor differentiation,,and TNM staging of non-small cell lung cancer.The tissue was divided into two groups,tumor tissue group and para-carcinoma tissue group.According to the process of preparation into the para-carcinoma tissue chip and tumor tissue chip.The immunohistochemical method(SP method)was used to stain the tissue microarray.The results of the immunohistochemistry were evaluated by the pathologist who had experienced the pathology department of Hunan Provincial Tumor Hospital.Results: Of the 69 cases,60 were male and 9 were female.Case type,squamous cell carcinoma in 38 cases,adenocarcinoma in 31 cases.Differentiation degree: poorly differentiated in 14 cases,medium differentiation in 45 cases,well differentiated in 5 cases,5 cases were not applicable to this classification.Age,39 patients over 60 years of age,30 patients younger than 60 years of age.TNM staging based on the January 2017 implementation of the International Union Against Cancer(UICC)eighth edition of lung cancer staging criteria for patients staging.T1 in 11 cases,T2 in 38 cases,T3 in 14 cases,T4 in 6 cases;N0 in 22 cases,19 cases of N1,N2 in 28 cases.Phase II and Phase II of the following 33 cases,more than 36 cases of stage II.No lymph node metastasis in 22 cases,47 cases of lymph node metastasis.There were no expression(negative)in 53 cases(negative),16 cases(7 cases of squamous cell carcinoma and 5 cases of adenocarcinoma).There were 17 cases(negative)Including squamous cell carcinoma in 31 cases,26 cases of adenocarcinoma).The positive rate was 23.2% in the para-carcinoma tissues and 75.4% in the cancer tissues.The expression of transaldolase in cancer tissues was significantly different from that in para-carcinoma tissues(P <0.05).The expression of transaldolase in non-small cell lung cancer was not significantly correlated with gender,age,pathological type,tumor differentiation,T stage,TNM stage and stage II(P> 0.05),but was significantly correlated with Lymph node metastasis and N staging were significantly correlated(P <0.05).The expression of transaldolase in squamous cell carcinoma of squamous cell carcinoma was significantly different from that in squamous cell carcinoma(P <0.05).The expression of transaldolase in adenocarcinoma of para-carcinoma tissues was significantly different from that in adenocarcinoma(P <0.05).The expression level of transaldolase in non-small cell lung cancer was positively correlated with lymph node metastasis(P <0.05).Conclusion: The expression of transaldolase in non-small cell lung cancer tissues is significantly higher than that in para-carcinoma tissues and the expression level of transaldolase in non-small cell lung cancer patients is significantly correlated with lymph node metastasis.The expression of alcoholase was significantly increased.This study of the development of non-small cell lung cancer mechanism and its regulatory mechanism provides a new way of thinking and theoretical basis.