Study On The Safety And Efficacy Of Xenogenic Acellular Dermal Matrix In The Protection Of Recurrent Laryngeal Nerve

Purpose:Objective to investigate the efficacy and safety of using xenogenic acellular dermal matrix for the protection of recurrent laryngeal nerve in thyroid surgery,and to provide experimental evidence for the clinical practice.Method:1.According to the inclusion and exclusion criteria were determined,we selected 80 patients,were randomly divided into two groups,the experimental group were using the acellular dermal matrix covered on the anatomy of the recurrent laryngeal nerve after exposed,and proper fixation;the control group was not using acellular dermal matrix to protect recurrent laryngeal nerve.The anatomy of the recurrent laryngeal nerve after only be exclued.2.The operation time,bleeding volume and postoperative complications(including delayed hoarseness,wound effusion,wound infection,implant removal,transient hypocalcemia),long-term complications(including permanent hoarseness,permanent hypocalcemia),voice handicap index(VHI-10)in seventh days after operation and voice handicap index(VHI-10)in sixth months after operation,were recorded in each group.3.The operation time,intraoperative blood loss,the incidence of postoperative complications(including short-term and long-term complications),voice handicap index(VHI-10)were analyzed statistically by using SPSS 22 statistical software(P < 0.05,the difference was statistically significant).Results:1.The VHI-10 score in seventh days after operation of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).2.Compared with the control group,there was no significant difference in VHI-10 score in sixth months after operation between the experimental group(P>0.05).3.The experimental group of postoperative delayed hoarseness incidence was significantly lower than the control group,there was significant difference,with statistical significance(P<0.05).4.The operation time,intraoperative bleeding volume,postoperative wound effusion rate,transient hypocalcemia incidence rate,and the incidence of permanent hoarseness rate which in experimental group compared to the control group,there was no significant difference,not statistically significant(P>0.05).5.In the study,there were no permanent hypocalcemia,wound infection and implant removal in the experimental group and the control group.Conclusion:1.The use of acellular dermal matrix to protect recurrent laryngeal nerve to reduce postoperative delayed hoarseness incidence and the extent of hoarseness has a positive effect.2.It is safe and effective to protect the recurrent laryngeal nerve with xenogenic acellular dermal matrix...