Effects Of Butylphthalide And Sodium Chloride Injection On Cerebral Blood Flow And Neurological Function In Patients With Acute Cerebral Infarction

Objective:To observe the mechanism of butylphthalide and sodium chloride on the treatment of patients with acute cerebral infarction,and to improve the cerebral blood flow is the mechanism of butylphthalide in the treatment of acute cerebral infarction.Methods:A total of 60 cases of acute cerebral infarction were randomly divided into observation group and control group with 30 cases in each group,two groups of patients were given aspirin,atorvastatin and other conventional treatment,the study group on the basis of the treatment application of butylphthalamide and sodium chloride injection.The patients in the two groups were treated continuously for 14 days.Injection treatment efficacy of the two groups before and after treatment.According to NIHSS score,patients' neurological function were evaluated before and after treatments.TCD breath-hold test was used to measure cerebral blood flow,comparison of two groups before treatment,72 hours of treatment,7 days of treatment,14 days of treatment(PI),breath holding index(BHI),the average blood flow velocity(Vm).Results:(1)The total effective rate of the observation group was90.0%,the total effective rate of the control group was76.67%,and the total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(?2=6.13,P<0.05).(2)After treatment,NIHSS scores of the two groups was significantly lower than those before treatment(t=3.118,P<0.05),that of the observation group was significantly decreased(P<0.05).(3)There was no significant difference in PI,BHI and Vm between the two groups before treatment(P>0.05).and 72 hours,7 days,14 days after treatment two groups of patients with PI decreased in different degree,BHI and Vm increased,compared with PI,BHI,Vm on the 14 day of the two groups of patients,the difference was statistically significant(P<0.05).The control group with 72 hours,7 days of PI,BHI,Vm compared with before treatment,there was no statistically significant difference(P>0.05),the control group with 14 days of PI,BHI,Vm compared with before treatment,the difference was statistically significant(P<0.05).The observation group with 72 hours of PI,BHI,Vm compared with before treatment,there was no statistically significant difference(P>0.05).The observation group with 7 days,14 days of PI,BHI,Vm compared with 72 hours after treatment,the difference was statistically significant(P<0.05).A further 2-2 comparision,the observation group with 72 hours,7 days of PI,BHI,Vm compared with 14 days after treatment,the difference was statistically significant(P<0.05).Conclusions:Butylphthalamide and sodium chloride injection can improve the cerebral blood flow in patients with acute cerebral infarction,reduce the neurological deficit and accelerate the repair of brain tissue.Butylphthalamide and sodium chloride injection has obvious curative effect in treating acute cerebral infarction,the clinical treatment is effective and safety and it is worthy to be popularized and applied in clinical practice.