Tuberculosis Patient Serum Homocysteine Detection Reports And Distribution Characteristics Of The Research

Objectives: Were collected at the beginning of all ages and follow-up cure tuberculosis person fasting serum specimens,detection in the serum homocysteine levels,explore the homocysteine levels of population distribution as a result of age,gender and other reasons are also adapted to the tuberculosis(TB)the crowd,a person to evaluate whether patients with tuberculosis caused by infection of homocysteine levels in the body is abnormal,tuberculosis(TB)could lead to abnormal lipid metabolism and n/med tuberculosis medicaments sex kidney injury whether impact on its level will also,at the beginning of this research from the gender,age,social three factors analysis of TB homocysteine levels in the body,preliminary evaluation of TB patients this population overall serum homocysteine levels.Methods: Use German company roche diagnostics cobas 6000 full automatic biochemical analyzer instruments,using an open channel to installation and test of reagent,reagent selection Beijing wan ted co production of homocysteine detection reagent.Homocysteine chooses improved circulation enzymatic serological detection method,principle of methodology for oxidation of HCY was converted into free HCY,free HCY in CBS reaction under the catalysis and serine L-urinary sulfur ether.L-(sulfide and generated under the CBL catalytic HCY,pyruvic acid and NH3.The cycle of pyruvic acid can be detected with LDH and NADH lactate dehydrogenase,NADH into NAD rate is proportional to the HCY content in the samples.Results: The use of statistical methods to analyze 144 cases of test results.According to the sex,the male group 96 cases,48 cases,women are HCY value if there is a difference,first test F,F = 1.647,P < 0.05,the variance is not neat;So using Welch t test,t = 0.9165,P > 0.05,no statistical significance.Namely the relationship between men and women of HCY value no significant statistical differences(figure 1).With age as the abscissa,HCY value as the ordinate,draw a scatter diagram.By the graph,you can see that age and HCY value wireless sex.Further Pearson correlation test,correlation coefficient r = 0.097,P = 0.247,P > 0.05,no correlation between age and HCY values.Into two groups according to the initial visit,comparison of HCY value if there is a difference,first test F,F = 1.616,P > 0.05,variance together;Then using t test,t = 2.062,P = 0.041 < 0.05,with statistical significance.The HCY value statistically difference between the first diagnosis and follow-up.Discuss: According to the results of this study to detect tuberculosis person of sex and age on serum homocysteine levels in high and low has no statistical difference,the visit will be in addition to the combination of tuberculosis patients serum homocysteine type water ping a statistically significant difference,with the progress of the disease and anti-tb drugs,and liver and kidney injury caused by anti-tuberculosis medicine,are likely to become a leading to same type semifinished said the reason why you calculate level height,increased homocysteine levels and cardiovascular disease,pregnancy complications,cognitive impairment,and osteoporosis,and other disease are closely related and are thought to have an independent risk factor for coronary heart disease(CHD),so the TB patients monitoring serum homocysteine levels and take the corresponding treatment measures should also be our TB clinicians need to consider the problem.