Study On Compliance The Curative Effect Of CBT Combined With Eszopiclone To Treat Chronic Insomnia

Objective:Evaluation of the efficacy of CBT combined with Eszopiclone to treat chronic insomnia.Evaluate the compliance of CBT combined with Eszopiclone to treat chronic insomnia.Methods:The randomized control study of two groups of subjects included in the mental health center of Tianjin city from January 2016 to December 2016 in the outpatient complaints of chronic insomnia patients in 125 cases,screening by the general questionnaire,Beck score <17,PSQI subjects on chronic diagnostic criteria for insomnia from ICSD-3,66 cases.Divided into 2 groups: YZP+CBT 33 cases,given dexzopiclon study,the dosage of 1.5-3mg/d combined with the treatment of CBT 4weeks;YZP for 33 cases only give Eszopiclone oral,the dose of 1.5-3mg/d 4weeks.The clinical treatment effect before treatment and after second and 4 weeks with PSQI,ESS before and on the fourth weekend daytime sleepiness severity,by the TESS during the course of the study subjects the emergence of adverse reaction conditions,and evaluation of each treatment subjects during treatment adherence to treatment.In our study according to the consistency of the medication time and patient behavior and advice to evaluate the compliance of the 2 groups of subjects of treatment,and contact with the subjects and their guardian daily phone,to determine patient daily medication time consistency and patient behavior and medical conditions.The daily amount of medication for full compliance to 75%-100%,do not take medication or intermittent medication for 25%-75% partial compliance to stop treatment,excessive medication or medication compliance is less than 25%.In this study,a total of 66 subjects were randomly divided into YZP+CBTgroup and YZP group,after 4 weeks of study,the final completion of the study subjects were 62 cases,4 cases of loss.Among them,31 cases were completed by right clone group,2 cases were dropped.CBT was performed in 31 cases,and 2 cases were removed.Data analysis and statistical processing: SPSS22.0 statistical software was used for processing and analysis.The main statistical methods included repeated measures analysis of variance,t test,rank sum test and X2 test.The difference was statistically significant by P<0.05.Result:The completed a total of 62 cases,the study group completed 31 cases,the control group completed 31 cases.Two groups of subjects PSQI of the total score and each item score,in the treatment of fourth weeks were significantly lower than baseline,and the total score of CBT+YZP group compared with YZP group decreased more significantly,the difference was statistically significant(P<0.05).The two groups of subjects Epworth sleepiness scale score after 4 weeks treatment were compared with baseline levels before treatment also decreased significantly,while CBT+YZP group total score than single YZP group decreased more significantly,the difference was statistically significant(P<0.05).The sleep diary parameters in the study group before and after comparison,had different degrees of improvement.There was a significant difference in the sleep latency(SL)and the total awake time(TWT)between the 4 groups after treatment.Most importantly,the subjects' self perceived quality of sleep was better than before,and there was no statistical difference between the groups.The study group for the main adverse reactions are bitter and tired,and the main adverse reaction in the control group and the morning except pain dizziness,daytime sleepiness,fatigue,inattention.At the end of the fourth week,there was no statistically significant difference in the incidence of adverse events between the 2groups(P>0.05).The 2 groups of subjects between treatment compliance,compliance group better than the control group on the fourth week after treatment,the difference was statistically significant(P<0.05),the difference was statistically significant.Conclusion:1.The curative effect of right combination with CBT in treatment of chronic insomnia patients is better than that in the only right clone therapy group,and the effect is faster.2.CBT combined with right handed clone therapy and pure right handed clone therapy is safe,with less adverse reactions and mild adverse reactions.3.CBT can improve the compliance of subjects with insomnia in chronic insomnia patients.As a non drug treatment method,it is worthy of clinical promotion.