Determination Of Serum Hs-CRP And HCY In Migraineurs And Discussion On The Pathogenesis Of Migraine

Objective: Migraine is a chronic neurovascular disease that can directly lead to ischemic stroke,and the pathogenesis is not very clear,in recent years a large number of studies have shown that migraine is associated with an increased risk of ischemic stroke,but the precise association mechanism remain unclear.In this study,by examining the levels of stroke risk factors serum hs-CRP and Hcy in migraineurs,from a new perspective to explore the pathogenesis of migraine,so as to provide new control strategies.Methods: Migraine group selected from October 2016 to January 2017 in Shanxi Province People's Hospital of migraine patients treated,a total of 24 cases,all patients with migraine without aura,attack period migraine patients 10 cases,remission period migraine patients 14 cases;health control group selected from the hospital physical examination center and healthy volunteers,a total of 23 cases.Blood samples of both two groups were taken in the morning after a 8 h fast,through anticoagulation,centrifugation,machine analysis,serum levels of hypersensitive C-reactive protein were measured by scatter turbidimetry,serum levels of homocysteine were measured by rate method.All statistical analysis was conducted using SPSS(version 16)statistical software.Results: 1.Serum levels of hypersensitive C-reactive protein(mg/L)(results are expressed in Me±QR): Patients with migraine attacks(10 cases)3.65±1.14,patients during remission (14 cases)2.21±0.81,the control group(20 cases)0.77±0.33,patients with migraine attacks and patients during remission compared with the control group(P<0.05),patients with migraine attacks compared with patients during remission(P<0.05).2.Serum levels of homocysteine(umol/L)(results are expressed in Me±QR): migraine patients(24 cases)20.53±2.90,control group(23 cases)11.89±3.31,migraine group compared with the control(P<0.05).Conclusion: 1.The concentration of hs-CRP was found to be significantly higher in patients with migraine remission than in controls,suggesting that migraine patients in the remission period also exists inflammatory state,the concentration of hs-CRP was found to be significantly higher patients with migraine attacks than patients with migraine remission,further support for migraine attacks accompanied by enhanced inflammation;2.The concentration of HCY was found to be significantly higher in patients with migraine than in controls,suggesting that the release of HCY may be involved in the pathogenesis of migraine;3.The levels of serum hs-CRP and HCY in migraine patients were higher than those in the control group,suggesting that the two may be one of the potential associated mechanisms of migraine and ischemic stroke.