Progress On Personalized Medicines Of Diabetes Mellitus

Personalized medicine in the field of diabetes which based on the combination of traditional medicine,genomics and biological markers,means the precise diagnosis and guidance for the treatment of diabetes.Genetic testing could identify monogenetic diabetes and assist treatment,such as maturity-onset diabetes of the young(MODY),Neonatal diabetes mellitus(NDM)and mitochondrial gene mutation diabetes.Biological markers such as anti islet ? cell autoantibody and C peptide contributed to the accurate stratification and prognosis evaluation of diabetes.Pharmacogenomics mainly studies the effect of gene polymorphism of cytochrome P450 2C9(CYP2C9),organic cation transporters(OCTs)and peroxisome proliferator activated receptor gamma(PPAR?)on the efficacy of oral hypoglycemic agents,and provides reference to choose more effective hypoglycemic strategies.Although personalized medicine in the field of diabetes can not be accurate diagnosis and treatment,it will become a new trend in the future.