Research On The Effects Of Personalized Diet Intervention On The Oxidative Stress State Of Patients With Type 2diabetes In Xinjiang

Objective: 1)Acquaintance with diet status and oxidative stress levels of patients with type 2 diabetes mellitus in Xinjiang;2)Evaluation of influences of personalized diet intervention of type 2 diabetes mellitus patients on their rates of nutritional risks,nutrient intake and indexes of oxidative stress,glycometabolism,lipid metabolism and anthropometry.Methods: 160 patients with type 2 diabetes mellitus who were hospitalized at endocrinology department of the First Affiliated Hospital of Xinjiang Medical University from January,2016 to December,2016 were selected.These patients were evenly divided into two groups,a control group and an experimental group,in accordance with random numbers.During research,in addition to group requirements of diet,original DM therapeutic regimens and life styles of all T2 DM patients were strictly maintained for three months.On this basis,in the control group,diet intervention was carried out by giving regular diet health education of the hospital and conventional food exchange portions,while in the experimental group,patients received personalizeddiet intervention.By testing indexes of oxidative stress(contents of MDA in serum were tested to evaluate oxidative stress of patients;contents of SOD,Vitamin C and Vitamin E in serum were tested to evaluate antioxidant defense of patients),glycometabolism,lipid metabolism and change of anthropometry indexes of subjects of groups,improvement and correlation of various indexes before and after intervention were compared to analyze differences and influencing factors of oxidative stress levels.Results: 1)Findings of baseline: differences of the two groups in terms of demographic data,disease condition,and screening and scoring of nutritional risks showed no statistical significance(P>0.05).2)Comparison of indexes before and after intervention among the two groups: for patients in the experimental group after intervention,nutrient intake(carbohydrate,calcium,zinc,selenium,VC and VE),oxidative stress indexes(Superoxide Dismutase,vitamin C,vitamin E)and high-density lipoprotein cholesterol increased,andrates of nutritional risks,energy,fat,sodium,protein,malondialdehyde,glycometabolism,triglyceride,low-density lipoprotein cholesterin and the anthropometry index decreased where compared with the control group,their differences showed statistical significance(P<0.05).3)Comparison of indexes before and after intervention within each group: for patients in the experimental group after intervention,nutrient intake(carbohydrate,calcium,zinc,selenium,VC and VE),oxidative stress indexes(Superoxide Dismutase,vitamin C,vitamin E)and high-density lipoprotein cholesterol increased,and energy,fat,sodium,protein,malondialdehyde,glycometabolism,triglyceride,low-density lipoprotein cholesterin and the anthropometry index decreasedwith differences of statistical significance(P<0.05).In the control group,glycometabolism and triglyceride(TG)decreased,high-density lipoprotein cholesterin(HDL-C)increased where all of their differences showed statistical significance(P < 0.05)and differences of other indexes had no statistical significance(P>0.05).4)Results of difference comparison of the two groups before and after intervention: in respect of controlling indexes of oxidative stress,glycometabolism,lipid metabolism and anthropometry,the experimental group was better than the control group(P<0.05).5)Correlation analysis: Superoxide Dismutase was negatively correlated with glycometabolism,BMI and triglyceride and positively correlated with high-density lipoprotein cholesterin.Malondialdehyde was positively correlated with glycometabolism,BMI and triglyceride and negatively correlated with high-density lipoprotein cholesterin.Vitamin E was positively correlated with high-density lipoprotein cholesterin and negatively correlated with BMI and triceps skinfold thickness.All of them showed statistical significance(P <0.05).Conclusion:personalizeddiet intervention could improve nutrient intake and oxidative stress of patients with type 2 diabetes mellitus,decrease their glycometabolism levels,regulate their blood lipid,reduce or control risks of malnutrition.Thus,it is greatly beneficial to improvement of function of Insulin B cells and insulin resistance and can provide a theoretical basis for guiding patients with type 2 diabetes mellitus in respect of reasonable diet and improvement of life quality in Xinjiang.