The Investigation Of The Relation Between Group B Streptococcus Infection And Premature Rupture Of Membrane

Premature rupture of membrane(PROM)means rupture of membrane before parturient,which is caused by reproductive tract infections,the pressure increase of amnion cavity,uneven caul force,and shortage of nutrition.Infection is an important pathogenic factor of PROM.Group B Streptococcus(GBS)has the strongest penetrating power and the highest morbidity in the pathogene causing infection.GBS is normally lived in vagina and rectum.As the conditioned pathogen,it has the stronger adsorption capacity and penetrability for chorion.It can be attached to maternal tissues within 2h of inoculation,so as to invade in chorion.Phagocytosis of inflammatory cells and direct invasion of proteolytic enzyme caused by bacteria can reduce local tension of caul,resulting in PROM.At present,the prevention project of GBS mainly includes antibiotic precaution.Tolerance of global GBS has been increasing year by year in recent years.However,it still remains controversial by using prophylactic antibiotic therapy to cure GBS positive pregnant women.ObjectiveTo investigate the relation between group B streptococcus infection and premature rupture of membrane.To investigate the curative effect in the health of pregnant and the newborns about application of Sensitive antibiotics prophylactic treatment on the GBS positive gravidas in late pregnancy.Methods Collect 1211 cases of pregnant women from August 2015 to March 2016 for148 cases of pregnant women of premature rupture of membrane as experimental group,while collect 150 cases of normal pregnant women as control group.Compare the GBS infection rates of the two group.Research 62 cases of GBS positive gravidas in late pregnancy.Apply sensitive antibiotics prophylactic treatment on 20 cases of the study group,and the untreated 42 cases is contrasting group.ResultsGBS infection rates of experimental group(25.68%)is much higher than the control group(8.00%),and the difference has statistical significance.After comparing the different situation of premature rupture of membranes,preterm delivery,intrauterine infection,neonatal infection and puerperal infection among the groups,it shows that only the difference of incidence on intrauterine infection,neonatal infection and puerperal infection is not statistically significant between the study group and the contrasting group(P>0.05).The difference of premature rupture of membranes is not statistically significant between the study group and the contrasting group(P>0.05),There were 3 patients with premature in the treatment group,accounting for 15.00%;there were 8 patients with premature in the control group,accounting for 19.05%.There was no statistical significance in their difference(P>0.05).No patients had intrauterine infection in the treatment group and control group,accounting for 00.00% and 00.00%,respectively.There was no statistical significance in their difference(P>0.05).No patients had newborn infection in the treatment group and 3 patients had newborn infection in the control group,accounting for 0.00% and 7.14%,respectively.There was no statistical significance in their difference(P>0.05).There was no puerperal infection in the treatment group,but 5 lying-in women had puerperal infection in the untreated group,which occupied11.90%.There was no statistical significance in their difference(P>0.05).Conclusion(1)GBS infection in genital tract of pregnant women is a high-risk factor for premature rupture of membrane.(2)It is not effective to apply sensitive antibiotics prophylactic treatment on the GBS positive gravidas in late pregnancy to protect pregnant women and the newborns.