| Objective: To investigate the effects of atorvastatin calcium combined with folic acid and vitamin B12 on atherosclerosis in patients with hyperhomocysteine(HHcy).HHcy as an independent risk factor for atherosclerosis,folic acid,vitamin B12 is mainly to reduce the role of serum HHcy,and statins on the process of atherosclerosis to prevent,delay or even reverse the role.Methods: 120 cases of patients with carotid plaques and high homocysteinemia were divided into observation group(n=60)and control group(n=60)according to the random number table from October 2015 to December 2015.The observation group were given with atorvastatin calcium tablets 20 mg once every night;folic acid tablets 5 mg once daily;vitamin B12 tablets 0.5 mg once daily.The control group were given with atorvastatin calcium tablets 20 mg,once every night.The treatment time was 12 months.Were recorded in two groups of patients the following indicators.1 Two groups of patients with clinical effect.2 Before treatment,treatment for 6 months and 12 months after treatment,the levels of Triglyceride(TG),Total cholesterol(TC),Low density protein(LDL-C),and High density protein(HDL-C)were measured.3 Before treatment,treatment for 6 months and 12 months after treatment were treated with carotid artery color Doppler ultrasonography in both groups of carotid intima-media thickness(IMT),and the plaque type was evaluated,and two Group carotid plaque score.4 Before treatment,treatment for 6 months and 12 months after treatment,the serum homocysteine(Hcy),folic acid and vitamin B12 levels in the two groups were determined by ELISA5 Before treatment,treatment for 6 months and 12 months after treatment using ELISA method,two groups of serum monocyte chemotactic factor 1(MCP-1),interleukin 8(IL-8)levels.Result:1 The therapeutic effect: the total effective rate of the treatment group was higher than that of the control group(P<0.05).2 There was no significant difference in TG,TC,LDL-C and HDL-C between the two groups before treatment(P>0.05).Two groups were treated for 6 months and 12 months after TG,TC and LDL-C levels decreased significantly than that before treatment,while the level of HDL-C was significantly higher than that before treatment(P<0.05).The TG,TC and LDL-C levels of the observation group were lower than those of the control group at 6 months and 12 months after treatment,but the HDL-C level was higher than that of the control group(P<0.05).3 There was no significant difference in IMT level between the two groups before treatment(P>0.05).After treatment for 6 months and 12 months,the levels of IMT in the two groups were significantly decreased(P<0.05).and the level of IMT in the observation group was significantly lower than that in the control group(P<0.05),the difference was statistically significant.There was no significant difference between the two groups before treatment for unstable plaque(P>0.05),with the treatment time,two groups of unstable carotid plaque was significantly decreased(P<0.05),the observation group for 6 months,12 months of unstable plaque was significantly lower than the control group(P<0.05),the difference was statistically significant.4 There was no significant difference in serum Hcy,folic acid and vitamin B12 levels between the two groups(P>0.05).After treatment,the serum Hcy levels in the two groups were lower than those before treatment(P<0.05),and the serum Hcy level of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).5 There was no significant difference in MCP-1 and IL-8 before treatment between the two groups(P>0.05).After treatment for 6 months and 12 months,the MCP-1 and IL-8 levels in the two groups were significantly lower than those before treatment(P<0.05),and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:Atorvastatin calcium combined with folic acid and vitamin B12 can effectively stabilize atherosclerotic plaques with HHcyemia,regulate blood glucose and lipid levels and delay plaque progression.The mechanism of treatment may be related to folic acid and vitamin B12 can effectively reduce serum MCP-1,IL-8 levels,thereby inhibiting the early destruction of vascular wall damage. |
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