Study On The Relationship Between TCM Syndromes And Blood Lipid,Blood Hcy Level,Personality Traits In Patients Level,Personlity Traits In Patients With Mild Cognitive Impairment

Objective: To provide a new idea for the prevention and treatment of mild cognitive impairment by traditional Chinese medicine(TCM)and to dialectically provide objective evidence for clinics by studying the relationship between different TCM syndromes and blood lipid,blood Hcy level as well as personality traits in patients with mild cognitive impairment.Methods: A total of 244 patients with MCI admitted in the outpatient and inpatient departments in the Affiliated Hospital of Gansu University of Traditional Chinese Medicine from January 2016 to December 2016 were enrolled.The general clinical data,TCM information,blood lipid and blood Hcy level were collected and the EPQ personality survey was performed.The correlation between different syndromes and blood lipid,blood Hcy level as well as EPQ personality dimension was studied based on the dialectical classification by“Guiding Principles of Clinical Research on New Traditional Chinese Medicine”,statistical analysis was carried out using statistical software SPSS21.0.Result: 1.Among the 224 cases of MCI patients,117 cases(48%)were male,127 cases(52%)were female,the most of them were physical labor,constitution of primary school education and frequent physical exercise were relatively high(P < 0.05).There was no significant difference in age and gender.2.Classification of TCM syndromes were: kidney deficient encephala reduce(76,31.1%),phlegm obstructing orifices(67,27.5%),qi-stagnancy and blood stasis(59,24.2%),heart-spleen deficiency syndrome(25,10.2%),heart and liver deficiency(17,7.0%),among which,the proportion of kidney deficient encephala reduce was largest,the difference was statistically significant(P < 0.05).3.In this group of MCI patients,levels of TC and TG in phlegm obstructing orifices group were higher than the other four groups(P < 0.05);the LDL-C level in phlegm obstructing orifices group was higher than that in kidney deficient encephala reduce group and qi-stagnancy and blood stasis group(P <0.05);the order of the level of Hcy in different groups of MCI patients from high to low was: qi-stagnancy and blood stasis >kidney deficient encephala reduce,phlegm obstructing orifices > heart and liver deficiency,heart-spleen deficiency syndrome(P <0.05).There were no differences in HDL-C level among the five groups.4.Logistic regression analysis of different syndromes and blood index: Take kidney deficient encephala reduce as reference,the Hcy of blood is the Inverse influence factor of heart and liver deficiency(OR=0.796,P<0.05)and heart-spleen deficiency syndrome(OR=0.829,P<0.05);the TG of blood is the risk factor of phlegm obstructing orifices(OR=1.521,P<0.05);the Hcy of blood is the risk factor of qi-stagnancy and blood stasis(OR=1.164,P < 0.05).5.In this group of MCI patients,people with introversion personality was more than extroversion(P<0.05).Personality dimension of E grade in qi-stagnancy and blood stasis group was lower than the other four groups(P<0.05);N grade in heart and liver deficiency group was higher than the other four groups(P<0.05);dimension of P grade in different TCM syndrome groups had no significant differences(P>0.05).6.take kidney deficient encephala reduce as reference.N personality dimension is the risk factor of heart and liver deficiency(OR=1.144,P<0.05),E personality dimension is the inverse influence factor of qi-stagnancy and blood stasis(OR=0.901,P<0.05).Conclusion: 1.In this group of MCI patients,kidney deficient encephala reduce,phlegm obstructing orifices and qi-stagnancy and blood stasis were the common TCM syndromes in clinic,which should be paid attention to.2.The Hcy level of patients with MCI has a certain relationship among heart and liver deficiency,heart-spleen deficiency syndrome and qi-stagnancy and blood stasis.The level of TG has related to the phlegm obstructing orifices,which indicated that the levels of blood Hcy and TG could be the objective basis on MCI dialectically.3.In this group of MCI patients,Introverts and emotionally unstable personalities are more than extroverted and emotionally unstable personalities,in which qi-stagnancy and blood stasis,heart and liver deficiency have a strong relationship with Introverts and emotionally unstable personalities respectively,which indicated that psychological factors may be a newidea of MCI prevention and treatment.