Expression Of Serum Pancreatic Protein In The Chronic Obstructive Pulmonary Disease And Its Clinical Significance

Objective: To explore the clinical significance of serum pancreatic stone protein in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease by observing the expression of serum pancreatic stone protein(PSP/Reg)in acute exacerbation of COPD,remission and healthy people.Methods:seventy-five objects with AECOPD patients were selected.The acute exacerbation stage was taken as group A,group A was divided into three groups according to the condition: mild group(group A1),moderate group(group A2)and severe group(group A3).The remission period of group A was treated as group R,group R was divided into group R1,group R2 and group R3.Twenty-six healthy subjects was treated as the control group(group H).The objects with sputum culture positive in group A was treated as group S and patients in group S after accepting treatment with negative sputum culture was treated as group S1.The age,sex and CAT scores were collected and the fasting venous blood of group A,R and H was collected to measure PSP/Reg.The levels of procalcitonin(PCT),c-reactive protein(CRP),interleukin-6(IL-6),erythrocyte sedimentation rate(ESR),white blood cell count(WBC),neutrophil count(N)and sputum culture were measured in group A.we measure sputum culture again for those patients with positive sputum culture after remission.The pulmonary function of group R was collected.The correlation between PSP / Reg and PCT,CRP,IL-6,ESR,WBC and N in group A and group S was observed.Results:The level of PSP / Reg in group A with acute stage was significantly higher than that in group R with emission stage,the difference was statistically significant(P <0.05).The levels of PSP / Reg in group A with acute stage and in group R with emission stage were significantly higher than those in group H with Health stage,the difference was statistically significant(P <0.05).The differences of serum serum PSP / Reg level in acute stage among A1,A2,A3 groups were significant(P<0.05),serum PSP / Reg level had a increasing trend.Serum PSP / Reg levels decreased significantly in group A2,A3,S after receiving treatmentand,the difference was statistically significant(P <0.05).The serum PSP / Reg level was positively correlated with CRP in the acute exacerbation stage.(P<0.05),and no correlation with other indexes(P>0.05).The serum PSP / Reg level was positively correlated with PCT and CRP in the sputum culture positive group.(P <0.01),and had no correlation with other indexes(P> 0.05).Conclusion: Serum PSP / Reg can be used as an index to evaluate the inflammatory infection in the lungs.It has a better diagnostic value in combination with the inflammatory indexes such as PCT and CRP.Serum PSP / Reg can be used as one of the effective indexes of AECOPD disease evaluation,clinical symptoms,acute exacerbations combined with the use of more conducive to the assessment of the patient’s condition.Serum PSP / Reg levels in the treatment before and after there are significant differences that may contribute to the evaluation of disease treatment.