The Clinical Study Of IL-13, TNF-α And HsC-RP In Patients With Chronic Obstructive Pulmonary Disease

OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is one of theleading causes of chronic morbidity and mortality in the United States and is projectedto rank fifth in 2020 as a worldwide burden of disease. COPD is an increasinglycommon problem in China. COPD is characterized by airway inflammation. Thecytokines involved in this inflammatory process are very important. The aim of theinvestigation is to discuss the relationship between the IL-13, hsC-RP,TNF-αand thepatients with COPD. Illuminate the clinical significance of the cytokines.METHODS: Fourty-six patients diagnosed as COPD in our hospital from OCT. 2005to Apr. 2006 (male 31, age 56—88 years, female 15, age 56—82years) and 20healthy adult (male 12 and female 8, age 18—41years) were choose inexperimentation. The experiment group was composed of the patients diagnosed asCOPD and divided into two groups, stable group and an exacerbation group. Thehealthy people as control group. The COPD group was divided into two groups bysex. And the COPD group is also divided into two groups by ciggrate. Mensurationthe level of IL-13 and TNF-αin plasm by ABC-Elisa. The level of hsC—RP inplasm also tested. The experiment's data were compared with control. RESULTS:The level of IL-13 , TNF-αand hsC-RP in plasm in aggravation COPD groupsignificantly increased than the stable group and the control(P＜0.05). The level of thecytokines in plasm of stable COPD group significantly increased than thecontrol(P＜0.05). The level of the cytokines in plasm of COPD group significantlyincreased than the control(P＜0.05). The results shew no significantly difference ingroup female and male. The level of the cytokines in plasm of smoking groupsignificantly increased than the group non-smoking(P＜0.05). IL-13 was significantlycorrelate with other s cytokines. CONCLUSION: COPD is a complex disease thought to be caused by a combination of environmental and idiosyncratic risk factors.Cigarette smoking is the most important environmental risk factor for thedevelopment of COPD, Tumour necrosis factor-α(TNF-α) is a proinflammatorycytokine, and elevated levels of TNF-αhave been found in the lung tissues viabronchial biopsies, bronchoalveolar lavage and induced sputum from COPD patients.Interleukin-13 (IL-13) is a multifunctional cytokine that is produced by Th2 cells. In astudy of transgenic mice, overexpression of IL-13 in the mouse lung can cause aphenotype that mirrors human COPD including emphysema, mucus metaplasia andmacrophage-, lymphocyte- and eosinophil-rich inflammation.IL-13, TNF-αandhsC-RP nearly correlate with the COPD. They also correlated with the infection whichmay aggravate the COPD.