Comparison Of The Efficacy Of Two Treatment Options For Brucellosis

Object: In order to development a better therapeutic schedule for brucellosis,we treated 120 cases acute brucellosis patient with triple-drug combination and double-drug combination,respectively,then,we compared the efficacy of the two treatment options,the better combination treatment would be selected for reducing the recurrence rate and improving the patient quality of life.Methods: A prospective,randomized clinical research was carried out,120 patients with acute brucellosis were enrolled,these patients were selected from November 2014 to June 2014 in shihezi university school of medicine,the diagnosis and treatment of the first affiliated hospital infection patients.Research object diagnostic criteria in accordance with < health industry standard of the People's Republic of China > the brookings bacillus disease diagnosis standard of WS269(2007).Clinical data of every individual were collected,including gender,age,occupation,contact history,thermal history,hyperhidrosis,joint pain score,(according to the NRS pain assessment scale for patients with pain intensity score),using random number table,120 patients were divided into experimental group and control group,each group had 60 cases,the treatment group scheme: rifampicin(600mg / time,1 time / day,6 weeks),doxycycline(100mg / time,2 times / day,6 weeks),levofloxacin(200mg / time,2 times / day,6 weeks);the control group treatment: rifampicin(600mg / time,1 time / day,6 weeks),doxycycline(100mg / time,2 times / day,6 weeks).Time of fever lasting,Time of hyperhidrosis and pain score changes as evaluation factor,respectively in 1st week,2nd weeks,6th weeks,three clinical indicators of assessment record,follow up 6 months after the end of treatment.Then,recurrence would be re-evaluate via three clinical indicators;also recorded the incidence of adverse reactions of the two groups of patients,using SPSS17.0 software package was used for statistical analysis.According to the standard of a = 0.05,P < 0.05 that was statistically significant..Results: 1.The difference of gender composition,age,and three major clinical parameters were not significant between the experimental group and the control group at baseline.(P>0.05).2.The difference of time of fever lasting was significant between the experimental groups and control group.(2.63±0.74 d vs 3.50±0.97,P < 0.05).3.In the treatment of 1,2,6 weeks,each group of joint pain score points before and after the treatment are the significant change(P < 0.001);The experimental group in the treatment of 1,2,6 weeks,before and after the treatment effect of sweat has significant change(P < 0.05),while the control group in the treatment of the first week,there was no significant change before and after the treatment effect of sweat(P = 0.063),in the treatment of 2,6 weeks,therapeutic effect has significant change(P < 0.001).4.In the first week of the treatment,the experimental group patients decline significantly greater than the control group(P = 0.014),in the treatment of 2,6 weeks,pain score decline in value of the two groups no significant difference(P > 0.05);In the treatment of week 1,sweat disappear time of significant differencebetween the two groups(P = 0.433);In the treatment of 2,6 weeks,the experimental group sweat disappear time significantly shorter than the control group(P < 0.05).5.In the clinical treatment of white blood cell count index changes in the treatment of 6 weeks,before and after treatment in each group,and compared the two groups before and after treatment,there were no statistically significant difference(P > 0.05).6.Through the analysis of the two groups of adverse reactions,no statistically significant difference(chi-square = 0.152,P = 0.152).7.Two groups of curative effect through the comparative analysis of the experimental group curative effect significantly better than the control group,the difference was statistically significant(P = 0.003).8.After the treatment were followed up for 6 months,the experimental group recurrence rate was 3%,the control of the recurrence rate was 17%,the experimental group recurrence rate is lower than the control group,the difference was statistically significant(P = 0.027).Conclusion: 1.Rifampin,doxycycline,levofloxacin triple drug combination therapy clinical curative effect is better than that of rifampin,doxycycline two drugs combined,is a better clinical treatment options.2.Rifampin,doxycycline,levofloxacin three drug combination treatment process without serious adverse reactions,it is safety for the patients with acute brucellosis.