A Study Of The Correlation Between Incipient Graves Disease And Three Blood Cells

Objective: In recent years,the incidence of hyperthyroidism(hyperthyroidism)increased year by year.The Graves disease(GD)is the most important cause of hyperthyroidism.GD is an autoimmune disease.And it often associated with multiple organ damage,which combined with blood system damage is not uncommon.It is more common that GD patients received anti-thyroid drugs treatment had the emergence of white blood cell abnormalities,but some GD patients in the initial onset,has not yet received any anti-thyroid treatment has been white blood cell abnormalities,and even peripheral blood three cell abnormalities.Some patients with the outside Department of blood cell abnormalities as the first symptom of treatment,and then diagnosed as GD,these patients in thyrotoxicosis control,peripheral cell abnormalities also will be improved;at the same time peripheral blood three cell abnormalities significantly affect the treatment program of GD,so understand the impact Peripheral blood three lines of the relevant factors,clear its pathogenesis is particularly important.The experimental group tried to analyze the changes of peripheral blood cells and the influencing factors in the peripheral blood of patients with primary GD,and to explore the characteristics and possible pathogenesis of primary GD with peripheral blood three-line cell abnormality.Methods: A total of 431 patients were enrolled in a tertiary hospital from January 2014 to December 2015.They were diagnosed as GD for the first time and none of the patients treated with anti-thyroid as the initial GD group.300 patients with concurrent physical examination Normal population as a normal control group,do retrospective analysis.To compare the differences of thyroid hormone and peripheral blood three-line cells between the initial GD group and the normal control group,and to analyze the factors related to the abnormality of the three-line cell index of peripheral blood in GD group,and to identify the abnormalities of peripheral blood three-line cells What factors are involved.Thyroid hormone and antibodies were analyzed to identify the risk factors for abnormalities in peripheral blood triploid cells.Results:1.Compared with the normal control group,the white blood cell count(WBC),lymphocyte absolute value(L)and lymphocyte percentage(L%)in the initial GD were significantly higher than those of normal control group(P <0.05),and the difference was statistically significant(MCH),mean erythrocyte hemoglobin concentration(MCHC),mean platelet volume(MPV),platelet count(PCT),platelet distribution width(PDW),mean hematocrit(P <0.05).2.There was a negative correlation between WBC and FT3 and FT4(P <0.05).There was a negative correlation between GR and FT3,FT4,Tg Ab(P <0.05).And TSH was positively correlated with GR(P <0.05).There was a negative correlation between HGB and FT3 and FT4(P <0.05).There was a negative correlation between PLT and FT3(P <0.05).3.The initial incidence of GD combined with leukopenia in 20 cases,the incidence rate of 4.6%.The incidence of granulocytopenia was 51.8%,which was significantly higher than that of the normal control group(5.3%),and the difference was statistically significant(P <0.05).4.The initial GD combined with anemia in 73 cases.The incidence was 1 6.9%.The initial combination of GD and anemia in 16 cases of male patients,57 females;1 case of moderate anemia,the remaining 72 cases were mild anemia.5.The initial GD combined with thrombocytopenia in 13 cases.The incidence was 2.9% was significantly higher than the normal control group and the incidence of thrombocytopenia 0.7%,the difference was statistically significant(P <0.05).6.The age ?FT4?Tg Ab of patients with the initial GD complicated with leukopenia was significantly higher than that of primary GD patients without leukopenia(P <0.05).Regression analysis showed that age,Tg Ab was risk factors for the primary GD with leukopenia.7.The levels of FT3 and FT4 in patients with the initial GD with myelopenia were significantly higher than those of the initial GD patients with non-granulocytopenia(P <0.05).At the same time,TSH was significantly lower in patients with the initial GD combined with granulocytopenia than those with the initial GD without granulocytopenia(P <0.05).Regression analysis showed that FT4 was a risk factor for the initial GD with granulocytopenia.8.The incidence of FT3 was significantly higher in patients with anemia than those without anemia(P <0.05),and the difference was statistically significant(P <0.05).Regression analysis showed that FT3 was a risk factor for the initial GD with anemia.Conclusion: This study found that patients with newly developed GD,without any anti-thyroid drugs before treatment,there have been abnormal peripheral blood cells.1.The percentage of neutrophils in patients with newly developed GD was significantly lower than that in the normal control group,but the WBC was significantly higher than that in the normal control group,which was significantly correlated with the absolute value and the percentage of lymphocytes,and the lymphocytes were significantly higher in the early stage Improve the changes of lymphocyte subsets.2.The WBC of GD was negatively correlated with FT4 and FT3.GR was negatively correlated with FT3,FT4 and Tg Ab,and positively correlated with TSH.The risk factors for early-onset GD-associated leukopenia were age,Tg Ab;11.8% of newly diagnosed GD patients had reduced granulocytopenia,FT4 was a risk factor for their incidence;patients with significantly elevated levels of FT4 should pay attention to their granulocytopenia occur.3.The levels of HGB,MCH and MCHC in the newly developed GD group were significantly lower than those in the normal control group.Early development of GD patients with HGB and FT3,FT4 was negatively correlated.The incidence of anemia combined with anemia was 16.9%.The risk factors were FT3,mostly in women,mostly mild anemia.Most types of anemia were positive pigment and small cell hypochromic anemia.4.The MPV?PCT and PDW were significantly lower in GD patients than those in normal controls.Early onset of GD patients with thrombocytopenia was 2.9%,such as early detection of patients with MPV?PCT?PDW decreased significantly,should be careful medication,positive observation of platelet changes.