Analysis Of Correlation Between Leptin And Thyroxine With Chronic Obstructive Pulmonary Disease

Objective: To investigate the chronic obstructive lung disease(COPD)acute attack period and stable period and healthy population changes in the control of leptin and thyroid function to clarify leptin and thyroid hormone in the pathogenetic condition and prognosis of patients with chronic obstructive pulmonary disease(COPD)judgement.Method: 1.Research objects: 1.1 Group COPD: In our hospital from January 2014 to December 2015 50 cases of hospitalized male patients with acute COPD exacerbation,who were admitted to the D based on COPD before admission,age 55-75 years old,the average age of 62.7 years.BMI was 19-24kg/m2,the average BMI was 21.1kg/m2.All patients were diagnosed according to Chinese Thoracic Socity,chronic obstructive pulmonary disease study group to develop the "chronic obstructive pulmonary disease diagnosis and treatment guidelines"(revised version of the 2013)COPD acute exacerbation and the remission criteria.1.2 Control group: Select healthy male hospital physical examination in 30 cases as control group,aged 55-75 years old,the average age of 62.9 years.BMI was 19-24kg/m2,the average BMI was 21.3kg/m2 2.Methods: The patients with acute exacerbation were drowed blood in the next morning as the acute period blood;After treatment of symptoms,again in the morning drowing blood samples as remission.The control group on the examination day fasting blood.Indicator for the detection of serum leptin and thyroid function parameters of TT3(serum three iodine thyroid original ammonia acid),TT4(serum thyroxine),FT3(serum free triiodothyronine triiodothyronine),FT4(serum free thyroxine),TSH(thyroid stimulating hormone)? Using SPSS17.0 statistical software,all the data were to(x_±s)said that between groups were compared with t test,P < 0.05 said there was a statistically significant difference..3.Result: 3.1 The determination of leptin: Comparison with the control group and stable period were higher leptin levels in the acute attack of COPD,which has statistical significance(P<0.05);leptin levels in stable COPD compared with the control group,the difference was not statistically significant(P>0.05)3.2: Determination of thyroid function: In acute stage of COPD compared with the control group,TT3 and FT3 decreased significantly,with statistical significance(P<0.05);Remission compared with the control group,TT3 and FT3 decreased slightly,but no statistical significance(P>0.05).During the period of acute attack and remission,compared with the control group COPD,FT4?TT4 and TSH was slightly decreased,but showed no significant difference(P>0.05).Conclusion: 1.Acute exacerbation and stable stage comparison with COPD,leptin levels increased significantly.With the consideration of the acute inflammation of important inflammatory markers,and respiratory function in patients with impaired.Leptin as a pro-inflammatory factor,and the interaction of inflammatory factor implicated in the inflammatory process,so leptin may be a marker for inflammatory exacerbations.Remission of leptin level was decreased,and the weight was positively related with leptin.This is likely to the body of a self protection reaction,because of low leptin levels is helpful to reduce energy consumption and stimulate feeding,so as to avoid a further decline in the weight loss and nutritional status of further deterioration in patients with chronic obstructive pulmonary disease(COPD).2.In acute stage of COPD compared with the control group,TT3 and FT3 decreased significantly,Remission compared with the control group,TT3 and FT3 decreased slightly,but no statistical significance.During the period of acute attack and remission,compared with the control group COPD,FT4?TT4 and TSH was slightly decreased,but showed no significant difference.Hypoxia,infection of cytokines and glucocorticoids cause changes in thyroid function.As this may be a protective mechanism of the body,with the improvement of the disease,thyroid function can be restored to normal or almost normal,suggesting that changes in thyroid hormone associated with the prognosis of COPD.3.Leptin and thyroxine has certain clinical value on the prognosis of COPD patients in the understanding of the disease,Clinicians should be pay attention.