Effect Of Early Continuous Venovenous Haemofiltration In Severe Acute Pancreatitis For The Prevention Of Local Pancreatic Complications

OBJECTIVE: To compare the conventional treatment and CVVH in the severe acute pancreatitis for the prevention of pseudocyst and abscess.PATIENTS AND METHODS: Forty two patients were divided into two treatment groups: Conventional treatment group contain 24 patients and CVVH 18.Conventional treatment group patients were treated symptomatically and according to the causes.CVVH group patients were treated symptomatically and CVVH was done within 2 hours of admission.RESULTS: In both the groups there was decrease in amylase,Lipase,CRP,IL-6,IL-10,TNF-alpha,RANSON SCORE,Balthazar score and APACHE-II SCORE after 72 hours,but decrease was more in CVVH patients.There were no any local pancreatic complications in CVVH patients but 1 patient had an acute peripancreatic fluid collection(APFC),2 patients had Pseudocyst,and 2 patients had walled-off necrosis(WON)and mortality one was seen in conventional treatment group.Conclusions: Our study shows that early CVVH can prevent the formation pseudocyst and abscess in SAP patients.