The Correlation Between Thytotropin And Serum Lipid Profiles In Euthyroid Patients With Newly Diagnosed Type 2 Diabetes

Objective: The association between thytotropin and lipid profiles in euthyroid diabetic patients is doubtful.We aimed to determine the association of thyroid stimulating hormone(TSH)in euthyroid patients with newly diagnosed type 2 diabetes and lipid profiles,and assess whether prevalence of hyperlipiodemia was associated with TSH level in diabetes mellitus.Methods: A total of 436 euthyroid patients with newly diagnosed type 2 diabetes(44.3% women)were evaluated.According to the level of TSH,all patients were divided into A group and B group(the group of low TSH level was A group,the group of high TSH level was B group).Clinical and demographic information was collected from all subjects.All blood samples were drawn in the morning after an overnight fasting in order to measure serum TSH,free thyroxine(FT4),free triiothyronine(FT3),as well as lipid concentrations and other biochemical indicators.The difference of age,BMI,blood pressure,glucose and lipid metabolism index between two groups were compared in overall,male and female patients respectively.correlation analysis was applied in assessing whether there is correlation between TSH and lipid profiles.Results: The mean BMI in A group was lower than B group(P=0.01),Log FT3 and Log FT4 were associated with TC,Log TG and Log HDL-C respectively in a Pearson correlation test,but not TSH.In females,total cholesterol(TC)was significantly higher in subjects of A group than B group(P = 0.03),and TSH was associated with TC and Log HDL-C in a Pearson correlation test,however,the significant association slipped up after adjusting for age,sex,smoking,BMI,blood pressure,FPG,HBA1 C,FT3 and FT4.In males,TSH was significantly associated with TC in a partial correlation analysis(P = 0.023),even in a multiple linear regression analysis,TSH was positively associated with TC(? = 0.05,P = 0.032).Among two groups stratified by TSH,the differences were not significant above the prevalence of hypercholesterolemia,high triglyceride and high LDL-C in a Person's X2 test.Conclusion: Serum TSH level was significantly associated with the level of TC independent of thyroid hormones in euthyroid men with newly diagnosed type 2 diabetes.