Clinical Research On The Treatment Of Anaphy Lactoid Purpura Nephritis In Children(shirexieyu Syndrome) By Qing Re Hu Ashi Quyu Prescription Combined With Losartan

Objective: To observe the clinical efficacy of Qingrehuashiquyu prescription combined with Losartan in the treatment of Henoch-Schonlein purpura nephritis in children(Shirexieyu Syndrome),and to explore the unique feasibility and security of combined Qingrehuashiquyu prescription in the treatment of children with purpura nephritis on the basis of strategy of western medicine.to provide clinical thinking and clinical basis for the treatment of Henoch Schonlein purpura nephritis in children with integrated traditional Chinese and Western medicineMethods: From the december 2015 to december 2016,50 cases of children diagnosis of Henoch-Schonlein purpura nephritis,as well as clinical syndrome differentiation of patients with damp-heat syndrome in Gansu provincial hospital of traditional chinese medicine of nephrology.According to the principle of Randomized control divided into treatment group and control group of each 25 cases.In the two groups were given losartan by western medic-ine clinical treatment strategy at the same time,The treatment group treat with Qingrehuashiquyu decoction,the control group treated with Huangkui capsule,treatment for 1 month,After treatment,the TCM syndrome integral and purpura severity,24-hour urinary protein,urinary sediment erythrocyte count and urinary NAG enzyme were statistically analyzed before and after the treatment.Results: The degree of skin purpura,24-hour urinary protein quantification,urinary sediment Erythrocyte count,curative efficacy of urinary NAG enzyme: both groups were improved after treatment(P<0.01);Qingrehuashiquyu group improved more than Huang kui capsule group.(P<0.05).5 cases in Qingrehuashiquyu prescription group cured with 24 hour urinary protein,the total effective rate was 92%,3cases in Huangkui capsule group were cured and the total effective rate was 84%.By the rank analysis,the difference was statistically significant(P<0.05).7 cases in Qingrehuashiquyu prescription group cured with urinary sediment Erythrocyte count,the total effective rate was 88%,3cases in Huangkui capsule group were cured and the total effective rate was 80%.By the rank analysis,the difference was statistically significant(P<0.05).(2)As for the TCM syndrome integral of two groups,all groups comparison between before and after treatment,all were improved(P<0.01).Comparison between groups after treatment,Qingrehuashiquyu group improved more than Huangkui capsule group(P<0.01);For as the TCM syndrome curative effect,5 cases in Qingrehuashiquyu prescription group were cured,the total effective rate was 92%,and 3cases in Huangkui capsule group were cured with the total effective rate was 68%.The difference was statistically analyzed by rank and test.The difference between the two groups was statistically significant(P <0.05).Conclusion: Qingrehuashiquyu prescription combined with losartan in the treatment of children with allergic purpura nephritis with Shirexieyu syndrome can improve the clinical manifestations and laboratory indexes of children with Shirexieyu syndrome,which with the better clinical safety.