Study On The Plasticity Of BOLD-fMRI And DTI In Patients With Aphasia

Section? Study on the plasticity of resting state BOLD-fMRI in patients with Broca aphasia Objective:The blood oxygenation level dependent functional MRI(BOLD-fMRI)after the amplitude of low-frequency fluctuation(ALFF)algorithm based on stroke Broca aphasia patients in acute stage and recovery after local brain activity changes,to explore the Broca aphasia and recovery mechanism.Methods:Using Siemens 3.0T MR scanner on 5 cases of acute phase after stroke(2 weeks)and rehabilitation(after 3 months)in patients with aphasia were scanned for resting state fMRI data,the dparsf software for resting state data preprocessing.Then the data were analyzed with the low frequency amplitude algorithm,and the REST software was used to Paired sample t test of the brain regions after the acute phase and the rehabilitation of the aphasia group.Results:Aphasia group in acute stage ALFF values decreased brain regions in the left middle temporal gyrus,left medial prefrontal gyrus and right cerebellum,the March after rehabilitation of the Encephalic Region ALFF value increased;aphasia group of acute ALFF values increased regions in the right image area of Broca's area,left occipital lobe,left insula,after March rehabilitation Alff this brain area value decreased.Conclusion:1.In the left middle temporal gyrus,left medial prefrontal gyrus,right cerebellum ALFF signal in aphasia group decreased obviously,the March after rehabilitation of the Encephalic Region ALFF values increased;and local lesions affect neuronal activity,which may be one of pathogenesis of aphasia.2.The ALFF signal of right mirror area of Broca area and the left occipital lobe and left insular lobe of the Broca region of the acute aphasia patients was higher than the normal,It can be considered that the functional reorganization of the brain areas involved in the language of the lesion side plays an important role in the recovery of language function.Section ? DTI Study on Broca aphasia due to cerebral white matter structure plasticity Objective:The changes of FA and ADC values of white matter fibers in the acute stage and recovery after stroke were studied by magnetic resonance diffusion tensor imaging(DTI)in order to explore the mechanism of Broca aphasia and recovery.Methods:Using Siemens Verio 3.0T MR scanner in 5 patients after stroke in acute phase(2 weeks)and recovery(after March)aphasia were obtained by scanning the resting DTI data,DTI image,costumes by DTI studio software to obtain the eddy current correction,anisotropic Broca area and arcuate fasciculus(FA),Apparent diffusion coefficient(ADC)value,using SPSS Statistic Chinese version of V17.0 software package for data processing,the left hemisphere aphasia group Broca,FA,arcuate fasciculus ADC paired t test,each part in Broca area,arcuate fasciculus FA,ADC aphasia group and control group,acute and aphasia in March after Broca,the arcuate fasciculus FA value and ADC value for independent samples t test.Results:Aphasia group in acute stage of left Broca's area FA value is 0.340±0.755.Left arcuate fasciculus FA value was 0.305±0.267,left Broca's area ADC value is 0.343±0.373,left arcuate fasciculus ADC value to 0.338±0.199,and normal group were significantly decreased compared;March after review of left Broca's area FA value was 0.485±0.391,left arcuate fasciculus FA value was 0.551±0.325,left Broca ADC values was 0.472±0.224,left arcuate fasciculus ADC value was 0.442±0.163,the values were compared with the acute stage of aphasia was significantly increased compared.Conclusion:1.Broca aphasia,in addition to the damage caused by the language functional area,the damage of its fiber pathway can lead to the occurrence of Broca aphasia,the recovery of white matter fibers in the recovery process of the language network.