Analysis Of Brain Microstructural Changes Of Motor Aphasia After Stroke By DTI And FMRI

Objective: To explore the changes of brain area of motor aphasia by DTI and rs-fMRI to study the changes of white matter fiber bundle and local brain metabolism in the brain language functional area of patients with motor aphasia after stroke.Methods: The case group consisted of 20 patients with exercise aphasia after the first stroke,while the control group consisted of 20 healthy volunteers.Substances in both groups were examined using a GE 3.0T magnetic resonance scanner.The scanning sequence included conventional cranial scan sequence,T1 structural image,diffusion tensor imaging and resting-state functional magnetic resonance imaging.The obtained images were post-processed by DTI Studio and DPABI.ROI was selected in the left Broca area,affected side and contralateral mirror area of the case group and the normal group on DTI images,and FA and MD values were determined.ALFF was measured on rs-fMRI images and two-sample t test was performed.Results: The FA value analysis showed that the left Broca area and the affected side area in the case group were lower than those in the normal control group and the contralateral mirror area,respectively,with statistical significance(P < 0.05).The MD value analysis showed that the left Broca area and the affected side of the case group were higher than the normal control group and the contralateral mirror area,respectively,with statistical significance(P<0.05).RS-fMRI analysis showed that ALFF values in the left brain stem,left lingual gyrus,left inferior temporal gyrus,right posterior cerebellar lobe,right cingulate gyrus,right superior frontal gyrus,left precuneus,left angular gyrus,left inferior frontal gyrus,and right medial frontal lobe decreased,while ALFF values in the right inferior frontal gyrus,right parhippocampal gyrus,and right middle frontal gyrus increased in the case group.Conclusion: DTI and rs-fMRI technology can analyze the language function area from the microscopic structure in patients with motor aphasia,which can provide imaging diagnostic basis for patients with motor aphasia after stroke,and provide certain basis for clinical treatment and rehabilitation prognosis.