The Variance Analysis Of Serum Vascular Endothelial Growth Factor In The Different Types Of Coronary Heart Disease

Objectives To investigate the serum level of vascular endothelial growth factor(VEGF)in patients with coronary artery disease(CAD)and its clinical significance.Methods 149 patients with CAD confirmed by clinical data and coronary angiography were identified form January 2016 to January 2017.The levels of VEGF were measured by ELISA.Patients divided into different groups according to clinical type or NYHA classification.VEGF levels in patients above different groups were analyzed.At the 6th month,took follow-up Secondary end points included angina pectoris,myocardial infarction,heart failure and cardiac death.Results 1 In the group with coronary artery vascular occlusion,VEGF averages 164.23 pg/ml,which significantly higher than those of coronary artery straightening lesion or coronary arteries revascularization group(P < 0.05).2 The VEGF value of STEMI group > the OMI group> CABG surgery group> NSTE-ACS group> PCI postoperative group.In addition to NSTE-ACS and PCI postoperative group,OMI and GABG postoperative group,any other two groups above the five have statistical significance(P < 0.05).3 B group of patients ’VEGF average higher than that of A group patients’ [128.9 pg/ml vs109.44 pg/ml].But the variance analysis between the two groups was no statistically significant difference(P > 0.05).4 NYHA Ⅲ[162.84±62.038 pg/ml] and NYHA Ⅱ[110.27±52.793 pg/ml]grade group had higher level of VEGF than NYHA Ⅳ[58.73±21.97 pg/ml] and NYHA Ⅰ[51.69±30.507 pg/ml].In addition to the NYHA Ⅰand NYHA Ⅳ grade groups’ VEGF level have no statistically significance.The rest of the each other groups had significantly statistical difference(P < 0.05).5 The highest incidence of Secondary end points during 6 month follow-up occurred in the group of cardiac function Ⅳ.Conclusions 1 The group of patients with coronary artery vascular occlusion have severe myocardial ischemia.Hypoxia-inducible factor stimulates the produce of VEGF.The markedly increase of VEGF reflects severe myocardial ischemia.2 VEGF reflects the degree of coronary artery stenosis.3 In the patients with light to moderate cardiac insufficiency,VEGF level is on the high side.But the VEGF value is on the low level in the patients with no cardiac insufficiency or severe heart failure patients.Therefore,according to the patients’ history of coronary heart disease,we can judge the patients with or without severe heart failure.4 VEGF levels were significantly lower in bad for the prognosis of patients with severe heart failure,as an index of evaluating the prognosis of patients with CHD.