Characteristics Of Cognitive Impairment In Patients With The Stenosis Of Various Degrees In Middle Cerebral Artery

Objectives: To observe the effect of middle cerebral artery stenosis on cognitive function,and to analyze the characteristics of cognitive impairment in patients with different degrees of stenosis.To provide evidence for early diagnosis and treatment of cognitive impairment in patients with middle cerebral artery stenosis or occlusion.Methods: According to whether the middle cerebral artery stenosis,98 patients with unilateral middle cerebral artery stenosis and 30 patients of normal control were enrolled in the study between December2015 to August 2016 in unilateral MCA stenosis in a military general hospital treatment in the nerve function examination room,according to the degree of stenosis,36 patients were divided into mild stenosis group,30 patients were divided into moderate stenosis group,32 patients were divided into severe stenosis or occlusion group,all the patients were given basic information collection and laboratory examination,at the same time,the cognitive function of both groups were evaluated by the Chinese version of the Montreal cognitive assessment(MOCA)and event related potential P300,comparing and analyzing the characteristics of each cognitive impairment.Results:(1)There was no significant difference between the stenosis group and the control group(P >0.05).Compared with the control group,the latency of P300 was prolonged and the amplitude decreased(P< 0.05).The scores of MoCA and cognitive domains in the stenosis group were lower than those in the control group.There were significant differences between the two groups in MoCA score,visual spatial /executive function,attention,language,abstraction,and delayed memory score(P < 0.05).In the stenosis group,the naming and orientation scores were lower than those in the control group.(2)There were significant differences in latency and amplitude of event related potential P300 between mild stenosis group,moderate stenosis group,severe stenosis or occlusion group and control group(P < 0.05).Mild stenosis group,moderate stenosis group,severe stenosis or occlusion group than in the control group,P300 latency was prolonged and the amplitude decreased(P < 0.05).In the moderate stenosis group,the latency of P300 was longer than that in mild stenosis group(P < 0.05),and the amplitude was similar(P > 0.05).In severe stenosis or occlusion group,the latency and amplitude of P300 were significantly lower than those of mild stenosis group and moderate stenosis group(P < 0.05).(3)Mild stenosis group,moderate stenosis group,severe stenosis or occlusion group and the control group between the four groups MoCA scores,visual space / executive function,attention,language,abstract,delayed memory score comparison(P <0.05).Mild stenosis group,moderate stenosis group,severe stenosis or occlusion group MoCA scores and the cognitive domain scores were lower than the control group,but only in the total score of MoCA,attention,language,abstract,delayed recall(P < 0.05).In the moderate stenosis group,the delayed recall score was lower than that in the mild stenosis group(P < 0.05),the total score of Mo CA and the scores of cognitive domains were not statistically significant(P > 0.05).Severe stenosis or occlusion group Mo CA scores and the cognitive domain scores were mild stenosis group,moderate stenosis group,but only in the total score of Mo CA,visual space / executive function,attention,delayed recall and abstract(P < 0.05).Conclusion:(1)Unilateral MCA stenosis affects cognitive function of patients,and it is more obvious in several cognitive domains such as visual space / executive function,attention,language,abstract,delayed memory(2)Different degrees of MCA stenosis on the cognitive function of patients with different cognitive domains and damage.