Effects Of Different Doses Of Cisatracurium On Motor Evoked Potential Of Neurosurgery Operation

Object: This study was designed to determine the effects of different doses of cisatracurium on motor evoked potential of neurosurgery operation.Methods: Sixty aged 18 to 65 years old and ASA class?-? patients scheduled for spinal surgery with motor evoked potential monitoring were included and randomly assigned to three groups.A single dose of cisatracurium besilate for injection was given by intravenous injection in 5s after the induction of general anesthesia,respectively 0.1mg/kg(group A),0.15mg/kg(group B)or 0.2 mg/kg(group C).Nicolet Cascade Elite 32 channel monitor of American company was used to monitor MEPs,Cooper's score was used to evaluate the intubation conditions.Results: The depressing time of the wave of motor evoked potentials was significantly longer in group C(39.60±1.79 min)than that in group A(20.10±1.89 min)and B(20.50±1.93 min)(P<0.05).The intubation conditions was significantly better in group B(100%)and C(100%)than that in group A(65%)(P<0.05).Conclusion: The shortest depressing twaveform time of MEPs using the dose of cisatracurium is0.15 mg/kg at induction of general anesthesia,Which has a better condition of tracheal intubation.The dose 0.15 mg/kg of cisatracurim is recommended as the initial dose on neurosurgery operation with motor evoked potential monitoring.